6V3F

Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005319	molecular_function	lipid transporter activity
A	0005886	cellular_component	plasma membrane
A	0006695	biological_process	cholesterol biosynthetic process
A	0008203	biological_process	cholesterol metabolic process
A	0008431	molecular_function	vitamin E binding
A	0009410	biological_process	response to xenobiotic stimulus
A	0014850	biological_process	response to muscle activity
A	0015485	molecular_function	cholesterol binding
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0030299	biological_process	intestinal cholesterol absorption
A	0030301	biological_process	cholesterol transport
A	0031267	molecular_function	small GTPase binding
A	0031489	molecular_function	myosin V binding
A	0031526	cellular_component	brush border membrane
A	0042157	biological_process	lipoprotein metabolic process
A	0042360	biological_process	vitamin E metabolic process
A	0042632	biological_process	cholesterol homeostasis
A	0042803	molecular_function	protein homodimerization activity
A	0051180	biological_process	vitamin transport
A	0070508	biological_process	cholesterol import
A	0071501	biological_process	cellular response to sterol depletion
A	1901363	molecular_function	heterocyclic compound binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	800
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	GLU21-PRO282
A	GLU374-ASP632
A	TYR687-LEU696
A	THR764-SER776
A	ASN868-GLY1113
A	TYR1164-ASN1165
A	LEU1228-ARG1242

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical; Name=1 => ECO:0000255

Chain	Residue	Details
A	GLY283-VAL303

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site_id	SWS_FT_FI3
Number of Residues	224
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	ARG304-PRO352
A	TYR654-LYS665
A	VAL718-SER742
A	ASP798-ARG846
A	ASP1135-ASN1142
A	THR1187-THR1206
A	SER1264-PHE1331

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
A	LEU353-ILE373

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
A	LEU633-SER653

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
A	ALA666-PHE686

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
A	VAL697-PHE717

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=6 => ECO:0000255

Chain	Residue	Details
A	VAL743-LEU763

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=7 => ECO:0000255

Chain	Residue	Details
A	GLY777-LEU797

---

site_id	SWS_FT_FI10
Number of Residues	20
Details	TRANSMEM: Helical; Name=8 => ECO:0000255

Chain	Residue	Details
A	PRO847-ILE867

---

site_id	SWS_FT_FI11
Number of Residues	20
Details	TRANSMEM: Helical; Name=9 => ECO:0000255

Chain	Residue	Details
A	ILE1114-LEU1134

---

site_id	SWS_FT_FI12
Number of Residues	20
Details	TRANSMEM: Helical; Name=10 => ECO:0000255

Chain	Residue	Details
A	LEU1143-SER1163

---

site_id	SWS_FT_FI13
Number of Residues	20
Details	TRANSMEM: Helical; Name=11 => ECO:0000255

Chain	Residue	Details
A	ALA1166-ILE1186

---

site_id	SWS_FT_FI14
Number of Residues	20
Details	TRANSMEM: Helical; Name=12 => ECO:0000255

Chain	Residue	Details
A	VAL1207-ILE1227

---

site_id	SWS_FT_FI15
Number of Residues	20
Details	TRANSMEM: Helical; Name=13 => ECO:0000255

Chain	Residue	Details
A	LEU1243-LEU1263

---

site_id	SWS_FT_FI16
Number of Residues	17
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN53
A	ASN506
A	ASN606
A	ASN626
A	ASN909
A	ASN917
A	ASN996
A	ASN1038
A	ASN1076
A	ASN85
A	ASN138
A	ASN244
A	ASN416
A	ASN431
A	ASN464
A	ASN479
A	ASN497

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