4IDT

Crystal Structure of NIK with 11-bromo-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2-amine (T28)

Summary for 4IDT

• Entry DOI: 10.2210/pdb4idt/pdb
• Related: 4IDV
• Descriptor: Mitogen-activated protein kinase kinase kinase 14, 11-bromo-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2-amine (3 entities in total)
• Functional Keywords: nik, nuclear factor (nf)-kb, p100 processing, 2-aminopyrimidine, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q99558
• Total number of polymer chains: 2
• Total formula weight: 79005.82

Authors

Liu, J.,Sudom, A.,Wang, Z. (deposition date: 2012-12-13, release date: 2013-04-17, Last modification date: 2024-02-28)

• Primary citation: Li, K.,McGee, L.R.,Fisher, B.,Sudom, A.,Liu, J.,Rubenstein, S.M.,Anwer, M.K.,Cushing, T.D.,Shin, Y.,Ayres, M.,Lee, F.,Eksterowicz, J.,Faulder, P.,Waszkowycz, B.,Plotnikova, O.,Farrelly, E.,Xiao, S.H.,Chen, G.,Wang, Z.; Inhibiting NF-KB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure activity relationship, and co-crystal structures; Bioorg.Med.Chem.Lett., 23:1238-1244, 2013; PubMed: 23374866; DOI: 10.1016/j.bmcl.2013.01.012

Experimental method

X-RAY DIFFRACTION (2.4 Å)