4IDT
Crystal Structure of NIK with 11-bromo-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2-amine (T28)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Mitogen-activated protein kinase kinase kinase 14 | polymer | 356 | 39173.7 | 2 | UniProt (Q99558) Pfam (PF00069) In PDB | Homo sapiens (human) | NF-kappa-beta-inducing kinase, HsNIK, Serine/threonine-protein kinase NIK |
| 2 | A, B | 11-bromo-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2-amine | non-polymer | 329.2 | 2 | Chemie (T28) | |||
| 3 | water | water | 18.0 | 317 | Chemie (HOH) |
Sequence modifications
A, B: 330 - 680 (UniProt: Q99558)
| PDB | External Database | Details |
|---|---|---|
| Gly 325 | - | expression tag |
| Ala 326 | - | expression tag |
| Met 327 | - | expression tag |
| Gly 328 | - | expression tag |
| Ser 329 | - | expression tag |
| Asp 549 | Ser 549 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 78347.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 658.4 | |
| All* | Total formula weight | 79005.8 |
