7LUS

IgG2 Fc Charge Pair Mutation version 1 (CPMv1)

Summary for 7LUS

Entry DOI	10.2210/pdb7lus/pdb
Descriptor	Immunoglobulin heavy constant gamma 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	fragment crystallizable, fc, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	50161.05
Authors	Sudom, A.,Whittington, D.,Garces, F.,Wang, Z. (deposition date: 2021-02-23, release date: 2021-09-15, Last modification date: 2023-10-18)
Primary citation	Estes, B.,Sudom, A.,Gong, D.,Whittington, D.A.,Li, V.,Mohr, C.,Li, D.,Riley, T.P.,Shi, S.D.,Zhang, J.,Garces, F.,Wang, Z. Next generation Fc scaffold for multispecific antibodies. Iscience, 24:103447-103447, 2021 Cited by PubMed: 34877503 DOI: 10.1016/j.isci.2021.103447 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation