7LUS
IgG2 Fc Charge Pair Mutation version 1 (CPMv1)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Immunoglobulin heavy constant gamma 2 | polymer | 207 | 23552.5 | 1 | UniProt (P01859) Pfam (PF07654) In PDB | Homo sapiens (Human) | Ig gamma-2 chain C region,Ig gamma-2 chain C region DOT,Ig gamma-2 chain C region TIL,Ig gamma-2 chain C region ZIE |
2 | A | Immunoglobulin heavy constant gamma 2 | polymer | 208 | 23681.9 | 1 | UniProt (P01859) Pfam (PF07654) In PDB | Homo sapiens (Human) | Ig gamma-2 chain C region,Ig gamma-2 chain C region DOT,Ig gamma-2 chain C region TIL,Ig gamma-2 chain C region ZIE |
3 | C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1463.3 | 2 | In PDB GlyTouCan (G80858MF) | |||
4 | water | water | 18.0 | 158 | Chemie (HOH) |
Sequence modifications
B: 237 - 443 (UniProt: P01859)
A: 237 - 444 (UniProt: P01859)
PDB | External Database | Details |
---|---|---|
Ala 378 | Ser 257 | variant |
Asp 392 | Lys 271 | engineered mutation |
Asp 409 | Lys 288 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Lys 356 | Glu 235 | engineered mutation |
Ala 378 | Ser 257 | variant |
Lys 399 | Asp 278 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 47234.3 | |
Branched | Number of molecules | 2 |
Total formula weight | 2926.7 | |
All* | Total formula weight | 50161.0 |