7LUS

IgG2 Fc Charge Pair Mutation version 1 (CPMv1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	Immunoglobulin heavy constant gamma 2	polymer	207	23552.5	1	UniProt (P01859) Pfam (PF07654) In PDB	Homo sapiens (Human)	Ig gamma-2 chain C region,Ig gamma-2 chain C region DOT,Ig gamma-2 chain C region TIL,Ig gamma-2 chain C region ZIE
2	A	Immunoglobulin heavy constant gamma 2	polymer	208	23681.9	1	UniProt (P01859) Pfam (PF07654) In PDB	Homo sapiens (Human)	Ig gamma-2 chain C region,Ig gamma-2 chain C region DOT,Ig gamma-2 chain C region TIL,Ig gamma-2 chain C region ZIE
3	C, D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1463.3	2	In PDB GlyTouCan (G80858MF)
4		water	water		18.0	158	Chemie (HOH)

Sequence modifications

B: 237 - 443 (UniProt: P01859)

PDB	External Database	Details
Ala 378	Ser 257	variant
Asp 392	Lys 271	engineered mutation
Asp 409	Lys 288	engineered mutation

A: 237 - 444 (UniProt: P01859)

PDB	External Database	Details
Lys 356	Glu 235	engineered mutation
Ala 378	Ser 257	variant
Lys 399	Asp 278	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47234.3
Branched	Number of molecules	2
	Total formula weight	2926.7
All*	Total formula weight	50161.0

*Water molecules are not included.