6V3H

Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) in complex with an ezetimibe analog

Summary for 6V3H

• Entry DOI: 10.2210/pdb6v3h/pdb
• EMDB information: 21037
• Descriptor: NPC1-like intracellular cholesterol transporter 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: cholesterol, transporter, tunnel, inhibitor, ezetimibe, lipid transport-inhibitor complex, lipid transport/inhibitor
• Biological source: Rattus norvegicus (Rat)
• Total number of polymer chains: 1
• Total formula weight: 153186.01

Authors

Huang, C.S.,Yu, X.,Min, X.,Wang, Z. (deposition date: 2019-11-25, release date: 2020-07-01, Last modification date: 2020-07-29)

• Primary citation: Huang, C.S.,Yu, X.,Fordstrom, P.,Choi, K.,Chung, B.C.,Roh, S.H.,Chiu, W.,Zhou, M.,Min, X.,Wang, Z.; Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition; Sci Adv, 6:eabb1989-, 2020; DOI: 10.1126/sciadv.abb1989

Experimental method

ELECTRON MICROSCOPY (3.5 Å)