6V3H
Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) in complex with an ezetimibe analog
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NPC1-like intracellular cholesterol transporter 1 | polymer | 1336 | 147640.2 | 1 | UniProt (Q6T3U3) Pfam (PF16414) Pfam (PF22314) Pfam (PF12349) | Rattus norvegicus (Rat) | Niemann-Pick C1-like protein 1 |
| 2 | B, C, D, E, F... (B, C, D, E, F...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 3 | H, I, J, K, L... (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 4 | N, O (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 2 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (60078761) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (73440805) PubChem (137392566) PubChem (137496323) PubChem (65082) PubChem (363416) PubChem (155804219) PubChem (99567469) PubChem (500055) PubChem (169132514) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (13301926) PubChem (13301927) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 5 | P (A) | 4-[(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-1-(4-{3-[(methylsulfonyl)amino]prop-1-yn-1-yl}phenyl)-4-oxoazetidin-2-yl]phenyl beta-D-glucopyranosiduronic acid | non-polymer | 698.7 | 1 | Chemie (QO1) PubChem (57940225) PubChem (91296841) PubChem (129143346) PubChem (11763920) PubChem (147444277) PubChem (11342976) PubChem (11422609) |
Sequence modifications
A: 21 - 1331 (UniProt: Q6T3U3)
| PDB | External Database | Details |
|---|---|---|
| Glu 1332 | - | expression tag |
| Asn 1333 | - | expression tag |
| Leu 1334 | - | expression tag |
| Tyr 1335 | - | expression tag |
| Phe 1336 | - | expression tag |
| Gln 1337 | - | expression tag |
| Gly 1338 | - | expression tag |
| Asp 1339 | - | expression tag |
| Tyr 1340 | - | expression tag |
| Lys 1341 | - | expression tag |
| Asp 1342 | - | expression tag |
| Asp 1343 | - | expression tag |
| Asp 1344 | - | expression tag |
| Asp 1345 | - | expression tag |
| Lys 1346 | - | expression tag |
| His 1347 | - | expression tag |
| His 1348 | - | expression tag |
| His 1349 | - | expression tag |
| His 1350 | - | expression tag |
| His 1351 | - | expression tag |
| His 1352 | - | expression tag |
| His 1353 | - | expression tag |
| His 1354 | - | expression tag |
| His 1355 | - | expression tag |
| His 1356 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 147640.2 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 2546.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2999.4 | |
| All* | Total formula weight | 153186.0 |
