6V3H
Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) in complex with an ezetimibe analog
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | NPC1-like intracellular cholesterol transporter 1 | polymer | 1336 | 147640.2 | 1 | UniProt (Q6T3U3) Pfam (PF16414) Pfam (PF22314) Pfam (PF12349) Pfam (PF02460) In PDB | Rattus norvegicus (Rat) | Niemann-Pick C1-like protein 1 |
2 | B, C, D, E, F... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
3 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
4 | A | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 2 | Chemie (Y01) | |||
5 | A | 4-[(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-1-(4-{3-[(methylsulfonyl)amino]prop-1-yn-1-yl}phenyl)-4-oxoazetidin-2-yl]phenyl beta-D-glucopyranosiduronic acid | non-polymer | 698.7 | 1 | Chemie (QO1) |
Sequence modifications
A: 21 - 1331 (UniProt: Q6T3U3)
PDB | External Database | Details |
---|---|---|
Glu 1332 | - | expression tag |
Asn 1333 | - | expression tag |
Leu 1334 | - | expression tag |
Tyr 1335 | - | expression tag |
Phe 1336 | - | expression tag |
Gln 1337 | - | expression tag |
Gly 1338 | - | expression tag |
Asp 1339 | - | expression tag |
Tyr 1340 | - | expression tag |
Lys 1341 | - | expression tag |
Asp 1342 | - | expression tag |
Asp 1343 | - | expression tag |
Asp 1344 | - | expression tag |
Asp 1345 | - | expression tag |
Lys 1346 | - | expression tag |
His 1347 | - | expression tag |
His 1348 | - | expression tag |
His 1349 | - | expression tag |
His 1350 | - | expression tag |
His 1351 | - | expression tag |
His 1352 | - | expression tag |
His 1353 | - | expression tag |
His 1354 | - | expression tag |
His 1355 | - | expression tag |
His 1356 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 147640.2 | |
Branched | Number of molecules | 6 |
Total formula weight | 2546.4 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 2999.4 | |
All* | Total formula weight | 153186.0 |