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8FYG
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BU of 8fyg by Molmil
Crystal structure of Hyaluronate lyase A from Cutibacterium acnes
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Hyaluronate lyase
著者Katiki, M, McNally, R, Chatterjee, A, Hajam, I.A, Liu, G.Y, Murali, R.
登録日2023-01-26
公開日2023-12-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Functional divergence of a bacterial enzyme promotes healthy or acneic skin.
Nat Commun, 14, 2023
8FNX
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BU of 8fnx by Molmil
Crystal structure of Hyaluronate lyase B from Cutibacterium acnes
分子名称: GLYCEROL, Hyaluronate lyase, PHOSPHATE ION
著者Katiki, M, McNally, R, Chatterjee, A, Hajam, I.A, Liu, G.Y, Murali, R.
登録日2022-12-28
公開日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Functional divergence of a bacterial enzyme promotes healthy or acneic skin.
Nat Commun, 14, 2023
8G0O
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BU of 8g0o by Molmil
Crystal structure of Y281F mutant of Hyaluronate lyase B from Cutibacterium acnes
分子名称: Hyaluronate lyase
著者Katiki, M, McNally, R, Chatterjee, A, Hajam, I.A, Liu, G.Y, Murali, R.
登録日2023-02-01
公開日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Functional divergence of a bacterial enzyme promotes healthy or acneic skin.
Nat Commun, 14, 2023
3VJE
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BU of 3vje by Molmil
Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus in complex with zaragozic acid A
分子名称: Dehydrosqualene synthase, Zaragozic acid A
著者Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J.
登録日2011-10-14
公開日2012-04-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
3VJD
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BU of 3vjd by Molmil
Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus
分子名称: Dehydrosqualene synthase, L(+)-TARTARIC ACID
著者Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J.
登録日2011-10-14
公開日2012-04-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
2ZY1
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BU of 2zy1 by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-830
分子名称: Dehydrosqualene synthase, dipotassium (2-oxo-2-{[3-(3-phenoxyphenyl)propyl]amino}ethyl)phosphonate
著者Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
登録日2009-01-10
公開日2009-09-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.
J.Med.Chem., 52, 2009
3W7F
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BU of 3w7f by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from staphylococcus aureus complexed with farnesyl thiopyrophosphate
分子名称: Dehydrosqualene synthase, MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE
著者Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E.
登録日2013-02-28
公開日2013-04-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
3ADZ
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BU of 3adz by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with intermediate PSPP
分子名称: Dehydrosqualene synthase, MAGNESIUM ION, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate
著者Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
登録日2010-01-31
公開日2010-11-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Mechanism of action and inhibition of dehydrosqualene synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
3AE0
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BU of 3ae0 by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with geranylgeranyl thiopyrophosphate
分子名称: Dehydrosqualene synthase, MAGNESIUM ION, phosphonooxy-[(10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]sulfanyl-phosphinic acid
著者Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
登録日2010-01-31
公開日2010-11-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Mechanism of action and inhibition of dehydrosqualene synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
8C5N
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BU of 8c5n by Molmil
Sub-atomic resolution structure of the chitin-binding protein D (CbpD) from Pseudomonas aeruginosa
分子名称: CHLORIDE ION, Chitin-binding protein CbpD
著者Cordara, G, Krengel, U, Golten, O, Vaaje-Kolstad, G, Vinther Soerensen, H.
登録日2023-01-09
公開日2023-06-28
最終更新日2023-07-26
実験手法X-RAY DIFFRACTION (0.75 Å)
主引用文献Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia.
Proc.Natl.Acad.Sci.USA, 120, 2023
3ACW
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BU of 3acw by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-651
分子名称: (3R)-3-biphenyl-4-yl-1-azabicyclo[2.2.2]octan-3-ol, Dehydrosqualene synthase
著者Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
登録日2010-01-13
公開日2010-11-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Mechanism of action and inhibition of dehydrosqualene synthase
Proc.Natl.Acad.Sci.USA, 107, 2010
3ACX
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BU of 3acx by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-673
分子名称: Dehydrosqualene synthase, N-(1-methylethyl)-3-[(3-prop-2-en-1-ylbiphenyl-4-yl)oxy]propan-1-amine
著者Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
登録日2010-01-13
公開日2010-11-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献Mechanism of action and inhibition of dehydrosqualene synthase
Proc.Natl.Acad.Sci.USA, 107, 2010
3ACY
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BU of 3acy by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-702
分子名称: (1R)-4-[3-(2-benzylphenoxy)phenyl]-1-phosphonobutane-1-sulfonic acid, Dehydrosqualene synthase, MAGNESIUM ION
著者Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
登録日2010-01-13
公開日2010-11-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Mechanism of action and inhibition of dehydrosqualene synthase
Proc.Natl.Acad.Sci.USA, 107, 2010
2ZCS
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BU of 2zcs by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-700
分子名称: Dehydrosqualene synthase, tripotassium (1R)-4-biphenyl-4-yl-1-phosphonatobutane-1-sulfonate
著者Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E.
登録日2007-11-11
公開日2008-03-11
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
2ZCQ
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BU of 2zcq by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-652
分子名称: (1R)-4-(3-phenoxyphenyl)-1-phosphonobutane-1-sulfonic acid, Dehydrosqualene synthase, MAGNESIUM ION
著者Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E.
登録日2007-11-11
公開日2008-03-11
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
2ZCO
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BU of 2zco by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus
分子名称: Dehydrosqualene synthase
著者Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E.
登録日2007-11-11
公開日2008-03-11
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
2ZCR
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BU of 2zcr by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-698
分子名称: Dehydrosqualene synthase, MAGNESIUM ION, tripotassium (1R)-4-(4'-butylbiphenyl-4-yl)-1-phosphonatobutane-1-sulfonate
著者Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E.
登録日2007-11-11
公開日2008-03-11
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
7BSL
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BU of 7bsl by Molmil
Crystal Structure of human ME2 R67A mutant
分子名称: NAD-dependent malic enzyme, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Chen, W.L, Tai, S.C, Hung, H.C, Ho, M.C.
登録日2020-03-30
公開日2021-02-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P) + -dependent malic enzyme.
Iscience, 24, 2021
7BSJ
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BU of 7bsj by Molmil
Crystal structure of human ME2 R484W
分子名称: FUMARIC ACID, MAGNESIUM ION, NAD-dependent malic enzyme, ...
著者Chen, W.L, Tai, S.C, Hung, H.C, Ho, M.C.
登録日2020-03-30
公開日2021-02-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P) + -dependent malic enzyme.
Iscience, 24, 2021
7BSK
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BU of 7bsk by Molmil
Crystal structure of human ME2 R67Q mutant
分子名称: NAD-dependent malic enzyme, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Chen, W.L, Tai, S.C, Hung, H.C, Ho, M.C.
登録日2020-03-30
公開日2021-02-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P) + -dependent malic enzyme.
Iscience, 24, 2021
5ZHQ
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BU of 5zhq by Molmil
Crystal structure of Scylla paramamosain arginine kinase
分子名称: Arginine kinase, SULFATE ION
著者Yang, Y, Jin, T.C, Liu, G.M.
登録日2018-03-13
公開日2019-03-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.002 Å)
主引用文献Crystal structure determination of Scylla paramamosain arginine kinase, an allergen that may cause cross-reactivity among invertebrates.
Food Chem, 271, 2019
4ZGZ
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BU of 4zgz by Molmil
STRUCTURE OF HUMAN ANTIZYME INHIBITOR IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME
分子名称: Antizyme inhibitor 1, Ornithine decarboxylase antizyme 1
著者Chen, S.F, Wu, H.Y, Chan, N.L.
登録日2015-04-24
公開日2015-09-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (5.81 Å)
主引用文献Structural basis of antizyme-mediated regulation of polyamine homeostasis
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZGY
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BU of 4zgy by Molmil
STRUCTURE of HUMAN ORNITHINE DECARBOXYLASE IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME
分子名称: MAGNESIUM ION, Ornithine decarboxylase, Ornithine decarboxylase antizyme 1, ...
著者Wu, H.Y, Chan, N.L.
登録日2015-04-24
公開日2015-09-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Structural basis of antizyme-mediated regulation of polyamine homeostasis
Proc.Natl.Acad.Sci.USA, 112, 2015
7XDG
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BU of 7xdg by Molmil
Cryo-EM structures of human mitochondrial NAD(P)+-dependent malic enzyme in a ternary complex with NAD+ and allosteric inhibitor MDSA
分子名称: 5-[(3-carboxy-4-oxidanyl-phenyl)methyl]-2-oxidanyl-benzoic acid, NAD-dependent malic enzyme, mitochondrial, ...
著者Wang, C.H, Hsieh, J.T, Ho, M.C, Hung, H.C.
登録日2022-03-27
公開日2023-03-29
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (2.84 Å)
主引用文献Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration
Commun Biol, 6, 2023
7XDF
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BU of 7xdf by Molmil
Cryo-EM structures of human mitochondrial NAD(P)+-dependent malic enzyme in a ternary complex with NAD+ and allosteric inhibitor EA
分子名称: 4-[(3-carboxy-2-oxidanyl-naphthalen-1-yl)methyl]-3-oxidanyl-naphthalene-2-carboxylic acid, NAD-dependent malic enzyme, mitochondrial, ...
著者Wang, C.H, Hsieh, J.T, Ho, M.C, Hung, H.C.
登録日2022-03-27
公開日2023-03-29
最終更新日2023-05-31
実験手法ELECTRON MICROSCOPY (2.72 Å)
主引用文献Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration
Commun Biol, 6, 2023

 

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