3VJE
Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus in complex with zaragozic acid A
Summary for 3VJE
Entry DOI | 10.2210/pdb3vje/pdb |
Related | 2ZCO 2ZCP 2ZCQ 2ZCR 2ZCS 2ZY1 3VJD |
Descriptor | Dehydrosqualene synthase, Zaragozic acid A (3 entities in total) |
Functional Keywords | crtm, carotenoid biosynthesis, staphyloxanthin biosynthesis, head-to-head condensation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 2 |
Total formula weight | 70772.27 |
Authors | Liu, C.I.,Jeng, W.Y.,Chang, W.J.,Wang, A.H.J. (deposition date: 2011-10-14, release date: 2012-04-11, Last modification date: 2023-11-08) |
Primary citation | Liu, C.I.,Jeng, W.Y.,Chang, W.J.,Ko, T.P.,Wang, A.H.J. Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase J.Biol.Chem., 287:18750-18757, 2012 Cited by PubMed: 22474324DOI: 10.1074/jbc.M112.351254 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.12 Å) |
Structure validation
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