3VJE
Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus in complex with zaragozic acid A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dehydrosqualene synthase | polymer | 293 | 34695.4 | 2 | UniProt (A9JQL9) | Staphylococcus aureus | Presqualene synthase, 4,4'-diapophytoene synthase, DAP synthase, Diapophytoene synthase |
| 2 | C, D (A, B) | Zaragozic acid A | non-polymer | 690.7 | 2 | Chemie (ZGA) PubChem (44308545) PubChem (21681278) PubChem (53315060) PubChem (53757375) PubChem (44287785) PubChem (44356045) PubChem (44318857) PubChem (56950392) PubChem (68363353) PubChem (68333335) PubChem (90701941) PubChem (124008) PubChem (101631777) PubChem (9831460) PubChem (9918010) PubChem (6438355) PubChem (133612333) PubChem (11422574) PubChem (134555398) PubChem (134939723) PubChem (9810194) PubChem (9874808) PubChem (9874809) PubChem (9896338) PubChem (9918011) PubChem (9939855) PubChem (15940206) PubChem (155887994) PubChem (155931769) PubChem (162875223) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 167 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 287 (UniProt: A9JQL9)
| PDB | External Database | Details |
|---|---|---|
| Ala -5 | - | expression tag |
| Ala -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Ala 248 | Tyr 248 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69390.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1381.5 | |
| All* | Total formula weight | 70772.3 |
