3VJE

Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus in complex with zaragozic acid A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Dehydrosqualene synthase	polymer	293	34695.4	2	UniProt (A9JQL9)	Staphylococcus aureus	Presqualene synthase, 4,4'-diapophytoene synthase, DAP synthase, Diapophytoene synthase
2	C, D (A, B)	Zaragozic acid A	non-polymer		690.7	2	Chemie (ZGA) PubChem (44308545)
3	E, F (A, B)	water	water		18.0	167	Chemie (HOH)

Sequence modifications

A, B: 1 - 287 (UniProt: A9JQL9)

PDB	External Database	Details
Ala -5	-	expression tag
Ala -4	-	expression tag
Ala -3	-	expression tag
Ala -2	-	expression tag
Ala -1	-	expression tag
Ala 0	-	expression tag
Ala 248	Tyr 248	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69390.8
Non-Polymers*	Number of molecules	2
	Total formula weight	1381.5
All*	Total formula weight	70772.3

*Water molecules are not included.