4ZGZ

STRUCTURE OF HUMAN ANTIZYME INHIBITOR IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME

Summary for 4ZGZ

Related4QCG 3BTN
DescriptorAntizyme inhibitor 1, Ornithine decarboxylase antizyme 1 (2 entities in total)
Functional Keywordstim barrel domain, beta-sheet domain, inhibition, antizyme, plasma, protein binding
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  O14977
Total number of polymer chains4
Total molecular weight126499.04
Authors
Chen, S.F.,Wu, H.Y.,Chan, N.L. (deposition date: 2015-04-24, release date: 2015-09-02, Last modification date: 2015-10-14)
Primary citation
Wu, H.Y.,Chen, S.F.,Hsieh, J.Y.,Chou, F.,Wang, Y.H.,Lin, W.T.,Lee, P.Y.,Yu, Y.J.,Lin, L.Y.,Lin, T.S.,Lin, C.L.,Liu, G.Y.,Tzeng, S.R.,Hung, H.C.,Chan, N.L.
Structural basis of antizyme-mediated regulation of polyamine homeostasis
Proc.Natl.Acad.Sci.USA, 112:11229-11234, 2015
PubMed: 26305948 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1508187112
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (5.81 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.238400.4%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution