2ZCS

Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-700

Summary for 2ZCS

Entry DOI	10.2210/pdb2zcs/pdb
Related	2ZCO 2ZCP 2ZCQ 2ZCR
Descriptor	Dehydrosqualene synthase, tripotassium (1R)-4-biphenyl-4-yl-1-phosphonatobutane-1-sulfonate (3 entities in total)
Functional Keywords	crtm, carotenoid biosynthesis, staphyloxanthin biosynthesis, transferase, head-to-head condensation, bisphosphonate
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	35272.12
Authors	Liu, C.I.,Jeng, W.Y.,Wang, A.H.,Oldfield, E. (deposition date: 2007-11-11, release date: 2008-03-11, Last modification date: 2023-11-01)
Primary citation	Liu, C.I.,Liu, G.Y.,Song, Y.,Yin, F.,Hensler, M.E.,Jeng, W.Y.,Nizet, V.,Wang, A.H.,Oldfield, E. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science, 319:1391-1394, 2008 Cited by PubMed: 18276850 DOI: 10.1126/science.1153018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation