2ZCS
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-700
Summary for 2ZCS
Entry DOI | 10.2210/pdb2zcs/pdb |
Related | 2ZCO 2ZCP 2ZCQ 2ZCR |
Descriptor | Dehydrosqualene synthase, tripotassium (1R)-4-biphenyl-4-yl-1-phosphonatobutane-1-sulfonate (3 entities in total) |
Functional Keywords | crtm, carotenoid biosynthesis, staphyloxanthin biosynthesis, transferase, head-to-head condensation, bisphosphonate |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 35272.12 |
Authors | Liu, C.I.,Jeng, W.Y.,Wang, A.H.,Oldfield, E. (deposition date: 2007-11-11, release date: 2008-03-11, Last modification date: 2023-11-01) |
Primary citation | Liu, C.I.,Liu, G.Y.,Song, Y.,Yin, F.,Hensler, M.E.,Jeng, W.Y.,Nizet, V.,Wang, A.H.,Oldfield, E. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science, 319:1391-1394, 2008 Cited by PubMed: 18276850DOI: 10.1126/science.1153018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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