3ACW

Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-651

Summary for 3ACW

Entry DOI	10.2210/pdb3acw/pdb
Related	2ZCO 2ZCP 2ZCQ 2ZCR 2ZCS 2ZY1 3ACX 3ACY
Descriptor	Dehydrosqualene synthase, (3R)-3-biphenyl-4-yl-1-azabicyclo[2.2.2]octan-3-ol (3 entities in total)
Functional Keywords	crtm, carotenoid biosynthesis, staphyloxanthin biosynthesis, transferase, head-to-head condensation, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	35066.87
Authors	Liu, C.I.,Jeng, W.Y.,Wang, A.H.J.,Oldfield, E. (deposition date: 2010-01-13, release date: 2010-11-24, Last modification date: 2023-11-01)
Primary citation	Lin, F.Y.,Liu, C.I.,Liu, Y.L.,Zhang, Y.,Wang, K.,Jeng, W.Y.,Ko, T.P.,Cao, R.,Wang, A.H.J.,Oldfield, E. Mechanism of action and inhibition of dehydrosqualene synthase Proc.Natl.Acad.Sci.USA, 107:21337-21342, 2010 Cited by PubMed: 21098670 DOI: 10.1073/pnas.1010907107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation