2ZY1
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-830
Summary for 2ZY1
Entry DOI | 10.2210/pdb2zy1/pdb |
Related | 2ZCO 2ZCP 2ZCQ 2ZCR 2ZCS |
Descriptor | Dehydrosqualene synthase, dipotassium (2-oxo-2-{[3-(3-phenoxyphenyl)propyl]amino}ethyl)phosphonate (3 entities in total) |
Functional Keywords | crtm, carotenoid biosynthesis, staphyloxanthin biosynthesis, transferase, head-to-head condensation, inhibitor |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 35213.00 |
Authors | Liu, C.I.,Jeng, W.Y.,Wang, A.H.J.,Oldfield, E. (deposition date: 2009-01-10, release date: 2009-09-01, Last modification date: 2023-11-01) |
Primary citation | Song, Y.,Liu, C.I.,Lin, F.Y.,No, J.H.,Hensler, M.,Liu, Y.L.,Jeng, W.Y.,Low, J.,Liu, G.Y.,Nizet, V.,Wang, A.H.J.,Oldfield, E. Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results. J.Med.Chem., 52:3869-3880, 2009 Cited by PubMed: 19456099DOI: 10.1021/jm9001764 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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