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3ACY

Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-702

Summary for 3ACY
Entry DOI10.2210/pdb3acy/pdb
Related2ZCO 2ZCP 2ZCQ 2ZCR 2ZCS 2ZY1 3ACW 3ACX
DescriptorDehydrosqualene synthase, (1R)-4-[3-(2-benzylphenoxy)phenyl]-1-phosphonobutane-1-sulfonic acid, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordscrtm, carotenoid biosynthesis, staphyloxanthin biosynthesis, transferase, head-to-head condensation, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceStaphylococcus aureus
Total number of polymer chains1
Total formula weight35288.28
Authors
Liu, C.I.,Jeng, W.Y.,Wang, A.H.J.,Oldfield, E. (deposition date: 2010-01-13, release date: 2010-11-24, Last modification date: 2023-11-01)
Primary citationLin, F.Y.,Liu, C.I.,Liu, Y.L.,Zhang, Y.,Wang, K.,Jeng, W.Y.,Ko, T.P.,Cao, R.,Wang, A.H.J.,Oldfield, E.
Mechanism of action and inhibition of dehydrosqualene synthase
Proc.Natl.Acad.Sci.USA, 107:21337-21342, 2010
Cited by
PubMed: 21098670
DOI: 10.1073/pnas.1010907107
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.84 Å)
Structure validation

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