3AE0
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with geranylgeranyl thiopyrophosphate
Summary for 3AE0
| Entry DOI | 10.2210/pdb3ae0/pdb |
| Related | 2ZCO 2ZCP 2ZCQ 2ZCR 2ZCS 2ZY1 3ADZ |
| Descriptor | Dehydrosqualene synthase, phosphonooxy-[(10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]sulfanyl-phosphinic acid, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | crtm, carotenoid biosynthesis, staphyloxanthin biosynthesis, transferase, head-to-head condensation, geranylgeranyl thiopyrophosphate, ggspp |
| Biological source | Staphylococcus aureus |
| Total number of polymer chains | 2 |
| Total formula weight | 71434.66 |
| Authors | Liu, C.I.,Jeng, W.Y.,Wang, A.H.J.,Oldfield, E. (deposition date: 2010-01-31, release date: 2010-11-24, Last modification date: 2023-11-01) |
| Primary citation | Lin, F.Y.,Liu, C.I.,Liu, Y.L.,Zhang, Y.,Wang, K.,Jeng, W.Y.,Ko, T.P.,Cao, R.,Wang, A.H.,Oldfield, E. Mechanism of action and inhibition of dehydrosqualene synthase. Proc.Natl.Acad.Sci.USA, 107:21337-21342, 2010 Cited by PubMed: 21098670DOI: 10.1073/pnas.1010907107 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.37 Å) |
Structure validation
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