3KTM
| Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP) | 分子名称: | (3R)-butane-1,3-diol, ACETATE ION, Amyloid beta A4 protein, ... | 著者 | Dahms, S.O, Hoefgen, S, Roeser, D, Schlott, B, Guhrs, K.H, Than, M.E. | 登録日 | 2009-11-25 | 公開日 | 2010-02-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein. Proc.Natl.Acad.Sci.USA, 107, 2010
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5MIM
| Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n | 分子名称: | 1-[(1~{R},2~{R},4~{S},5~{S})-2,4-bis(4-carbamimidamidophenoxy)-5-[(4-carbamimidamidophenyl)amino]cyclohexyl]guanidine, CALCIUM ION, CHLORIDE ION, ... | 著者 | Dahms, S.O, Guan-Sheng, J, Than, M.E. | 登録日 | 2016-11-28 | 公開日 | 2017-05-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor. ACS Chem. Biol., 12, 2017
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4RD9
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4RDA
| X-RAY STRUCTURE OF THE AMYLOID PRECURSOR PROTEIN-LIKE PROTEIN 1 (APLP1) E2 DOMAIN IN COMPLEX WITH A HEPARIN DODECASACCHARIDE | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, Amyloid-like protein 1, ... | 著者 | Dahms, S.O, Than, M.E. | 登録日 | 2014-09-18 | 公開日 | 2015-03-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | 主引用文献 | Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes. Acta Crystallogr.,Sect.D, 71, 2015
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6EQX
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6EQW
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6EQV
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7QY2
| X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 2 | 分子名称: | (2R)-4-[4-[5-[4-[[4-(acetamidomethyl)piperidin-1-ium-1-yl]methyl]-6-[3,5-bis(chloranyl)phenyl]pyridin-2-yl]oxypyrimidin-2-yl]piperazin-1-ium-1-yl]-2-methyl-butanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Dahms, S.O, Brandstetter, H, Pautsch, A. | 登録日 | 2022-01-27 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17, 2022
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7QXZ
| X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 5 | 分子名称: | 2-[(3S)-1-[[2-[3,5-bis(chloranyl)phenyl]-6-[2-(4-methylpiperazin-4-ium-1-yl)pyrimidin-5-yl]oxy-pyridin-4-yl]methyl]pyrrolidin-1-ium-3-yl]oxyethanoic acid, CALCIUM ION, CHLORIDE ION, ... | 著者 | Dahms, S.O, Brandstetter, H, Pautsch, A. | 登録日 | 2022-01-27 | 公開日 | 2022-04-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17, 2022
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7QY1
| X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[4-[5-[4-[[4-(acetamidomethyl)piperidin-1-ium-1-yl]methyl]-6-[3,5-bis(chloranyl)phenyl]pyridin-2-yl]oxypyridin-2-yl]piperazin-1-ium-1-yl]propanoate, CALCIUM ION, ... | 著者 | Dahms, S.O, Brandstetter, H, Pautsch, A. | 登録日 | 2022-01-27 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17, 2022
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7QXY
| X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 3 | 分子名称: | 3-[4-[5-[4-[[4-(acetamidomethyl)piperidin-1-ium-1-yl]methyl]-6-[3,5-bis(chloranyl)phenyl]pyridin-2-yl]oxypyrimidin-2-yl]piperazin-1-ium-1-yl]propanoate, CALCIUM ION, CHLORIDE ION, ... | 著者 | Dahms, S.O, Brandstetter, H, Pautsch, A. | 登録日 | 2022-01-27 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.478 Å) | 主引用文献 | Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17, 2022
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7QY0
| X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | 著者 | Dahms, S.O, Brandstetter, H, Pautsch, A. | 登録日 | 2022-01-27 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17, 2022
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3UMK
| X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with copper | 分子名称: | ACETATE ION, Amyloid beta A4 protein, CADMIUM ION, ... | 著者 | Dahms, S.O, Konnig, I, Roeser, D, Guhrs, K.H, Than, M.E. | 登録日 | 2011-11-13 | 公開日 | 2012-01-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain. J.Mol.Biol., 416, 2012
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3UMH
| X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with cadmium | 分子名称: | ACETATE ION, Amyloid beta A4 protein, CADMIUM ION | 著者 | Dahms, S.O, Konnig, I, Roeser, D, Guhrs, K.H, Than, M.E. | 登録日 | 2011-11-13 | 公開日 | 2012-01-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain. J.Mol.Biol., 416, 2012
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3UMI
| X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with zinc | 分子名称: | ACETATE ION, Amyloid beta A4 protein, CADMIUM ION, ... | 著者 | Dahms, S.O, Konnig, I, Roeser, D, Guhrs, K.H, Than, M.E. | 登録日 | 2011-11-13 | 公開日 | 2012-01-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain. J.Mol.Biol., 416, 2012
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4OMD
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4OMC
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7O1U
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7O22
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7O1Y
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7O1W
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7O20
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5JMO
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5JXH
| Structure the proprotein convertase furin in complex with meta-guanidinomethyl-Phac-RVR-Amba at 2.0 Angstrom resolution. | 分子名称: | 2UC-ARG-VAL-ARG-00S, CALCIUM ION, CHLORIDE ION, ... | 著者 | Dahms, S.O, Arciniega, M, Steinmetzer, T, Huber, R, Than, M.E. | 登録日 | 2016-05-13 | 公開日 | 2016-10-05 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
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5JMR
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