X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with cadmium

Summary for 3UMH

Related3UMI 3UMK
DescriptorAmyloid beta A4 protein, ACETATE ION, CADMIUM ION, ... (4 entities in total)
Functional Keywordsmetal binding site, metal binding, cell surface, secretory pathway, metal binding protein
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P05067
Total number of polymer chains1
Total molecular weight26192.19
Dahms, S.O.,Konnig, I.,Roeser, D.,Guhrs, K.H.,Than, M.E. (deposition date: 2011-11-13, release date: 2012-01-25, Last modification date: 2012-02-22)
Primary citation
Dahms, S.O.,Konnig, I.,Roeser, D.,Guhrs, K.H.,Mayer, M.C.,Kaden, D.,Multhaup, G.,Than, M.E.
Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain.
J.Mol.Biol., 416:438-452, 2012
PubMed: 22245578 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2011.12.057
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.236110.6%3.1%3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution