7QXZ
X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 5
Summary for 7QXZ
Entry DOI | 10.2210/pdb7qxz/pdb |
Descriptor | Furin, CALCIUM ION, SODIUM ION, ... (6 entities in total) |
Functional Keywords | proprotein convertase, inhibitor, sars-cov-2, protease, complex, furin, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 52889.47 |
Authors | Dahms, S.O.,Brandstetter, H.,Pautsch, A. (deposition date: 2022-01-27, release date: 2022-04-13, Last modification date: 2024-01-31) |
Primary citation | Dahms, S.O.,Schnapp, G.,Winter, M.,Buttner, F.H.,Schleputz, M.,Gnamm, C.,Pautsch, A.,Brandstetter, H. Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17:816-821, 2022 Cited by PubMed: 35377598DOI: 10.1021/acschembio.2c00103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report