Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n

Summary for 5MIM

DescriptorFurin, CALCIUM ION, SODIUM ION, ... (6 entities in total)
Functional Keywordsproprotein convertase, inhibitor, protease, complex, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationGolgi apparatus, trans-Golgi network membrane ; Single- pass type I membrane protein  P09958
Total number of polymer chains1
Total molecular weight53811.61
Dahms, S.O.,Guan-Sheng, J.,Than, M.E. (deposition date: 2016-11-28, release date: 2017-05-10, Last modification date: 2017-05-31)
Primary citation
Dahms, S.O.,Jiao, G.S.,Than, M.E.
Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
ACS Chem. Biol., 12:1211-1216, 2017
PubMed: 28402100 (PDB entries with the same primary citation)
DOI: 10.1021/acschembio.6b01110
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.185101.6%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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