5MIM

Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
AFurinpolymer48252388.61
UniProt (P09958)
Pfam (PF00082)
Pfam (PF01483)
Homo sapiens (Human)Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE
CALCIUM IONnon-polymer40.13
SODIUM IONnon-polymer23.04
CHLORIDE IONnon-polymer35.51
1-[(1~{R},2~{R},4~{S},5~{S})-2,4-bis(4-carbamimidamidophenoxy)-5-[(4-carbamimidamidophenyl)amino]cyclohexyl]guanidinenon-polymer587.72
waterwater18.0485

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains1
Total molecular weight52388.6
Non-Polymers*Number of molecules10
Total molecular weight1423.0
All*Total molecular weight53811.6
*Water molecules are not included.