5JXH

Structure the proprotein convertase furin in complex with meta-guanidinomethyl-Phac-RVR-Amba at 2.0 Angstrom resolution.

Summary for 5JXH

Related PRD IDPRD_001220
DescriptorFurin, 2UC-ARG-VAL-ARG-00S, CALCIUM ION, ... (6 entities in total)
Functional Keywordsprotease, inhibitor, proteolysis, hydrolase
Biological sourceHomo sapiens (Human)
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Cellular locationGolgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein P09958
Total number of polymer chains2
Total molecular weight53372.18
Authors
Dahms, S.O.,Arciniega, M.,Steinmetzer, T.,Huber, R.,Than, M.E. (deposition date: 2016-05-13, release date: 2016-10-05, Last modification date: 2016-10-19)
Primary citation
Dahms, S.O.,Arciniega, M.,Steinmetzer, T.,Huber, R.,Than, M.E.
Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113:11196-11201, 2016
PubMed: 27647913 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1613630113
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.185202.1%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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