5JXI

Structure of the unliganded form of the proprotein convertase furin in presence of EDTA.

Summary for 5JXI

DescriptorFurin, CALCIUM ION, SODIUM ION, ... (5 entities in total)
Functional Keywordsprotease, apo-structure, proteolysis, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationGolgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein P09958
Total number of polymer chains1
Total molecular weight52625.06
Authors
Dahms, S.O.,Arciniega, M.,Steinmetzer, T.,Huber, R.,Than, M.E. (deposition date: 2016-05-13, release date: 2016-10-05, Last modification date: 2016-10-19)
Primary citation
Dahms, S.O.,Arciniega, M.,Steinmetzer, T.,Huber, R.,Than, M.E.
Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113:11196-11201, 2016
PubMed: 27647913 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1613630113
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.18520.2%1.3%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution