3KTM

Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP)

Summary for 3KTM

DescriptorAmyloid beta A4 protein, (3R)-butane-1,3-diol, SULFATE ION, ... (5 entities in total)
Functional Keywordsprotein structure, alzheimer disease, amyloid, amyloidosis, apoptosis, cell adhesion, copper, disease mutation, disulfide bond, endocytosis, heparin-binding, metal-binding, neurodegeneration, notch signaling pathway, proteoglycan, zinc, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P05067
Total number of polymer chains8
Total molecular weight175534.1
Authors
Dahms, S.O.,Hoefgen, S.,Roeser, D.,Schlott, B.,Guhrs, K.H.,Than, M.E. (deposition date: 2009-11-25, release date: 2010-02-23, Last modification date: 2011-07-13)
Primary citation
Dahms, S.O.,Hoefgen, S.,Roeser, D.,Schlott, B.,Guhrs, K.H.,Than, M.E.
Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein.
Proc.Natl.Acad.Sci.USA, 107:5381-5386, 2010
PubMed: 20212142 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0911326107
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.250160.3%4.1%1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 3ktm
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Molmil generated image of 3ktm
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Molmil generated image of 3ktm
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3ktm.pdb6.gz [32.86 KB])
Coordinate files for Biological unit (3ktm.pdb8.gz [33.41 KB])
Coordinate files for Biological unit (3ktm.pdb12.gz [33.36 KB])
Coordinate files for Biological unit (3ktm.pdb11.gz [32.65 KB])
Coordinate files for Biological unit (3ktm.pdb3.gz [62.13 KB])
Coordinate files for Biological unit (3ktm.pdb1.gz [62.14 KB])
Coordinate files for Biological unit (3ktm.pdb10.gz [33.44 KB])
Coordinate files for Biological unit (3ktm.pdb9.gz [33.74 KB])
Coordinate files for Biological unit (3ktm.pdb2.gz [61.62 KB])
Coordinate files for Biological unit (3ktm.pdb7.gz [33.46 KB])
Coordinate files for Biological unit (3ktm.pdb4.gz [61.82 KB])
Coordinate files for Biological unit (3ktm.pdb5.gz [33.44 KB])