3KTM

Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008201	molecular_function	heparin binding
A	0016020	cellular_component	membrane
A	0046914	molecular_function	transition metal ion binding
B	0008201	molecular_function	heparin binding
B	0016020	cellular_component	membrane
B	0046914	molecular_function	transition metal ion binding
C	0008201	molecular_function	heparin binding
C	0016020	cellular_component	membrane
C	0046914	molecular_function	transition metal ion binding
D	0008201	molecular_function	heparin binding
D	0016020	cellular_component	membrane
D	0046914	molecular_function	transition metal ion binding
E	0008201	molecular_function	heparin binding
E	0016020	cellular_component	membrane
E	0046914	molecular_function	transition metal ion binding
F	0008201	molecular_function	heparin binding
F	0016020	cellular_component	membrane
F	0046914	molecular_function	transition metal ion binding
G	0008201	molecular_function	heparin binding
G	0016020	cellular_component	membrane
G	0046914	molecular_function	transition metal ion binding
H	0008201	molecular_function	heparin binding
H	0016020	cellular_component	membrane
H	0046914	molecular_function	transition metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BU4 A 1

Chain	Residue
A	THR83
A	ASN84
A	PRO173
A	CYS174
A	GLY175
A	ILE176

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BU4 B 7

Chain	Residue
G	ARG194
B	PRO188
B	LEU189
B	ALA190

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 2

Chain	Residue
B	ALA88
B	ASN89
B	ARG116
B	HOH209
B	HOH221
B	HOH226
H	ARG194

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT B 208

Chain	Residue
B	GLN90
B	HIS151
B	LYS155
H	ACT6

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BU4 C 5

Chain	Residue
A	ARG194
C	LEU189
C	ALA190

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 3

Chain	Residue
C	ASN89
C	ARG116
C	HOH210
C	HOH216
E	ARG194

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT C 8

Chain	Residue
C	GLN90
C	HIS151
E	ACT9
E	LYS155

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BU4 D 2

Chain	Residue
D	THR83
D	ASN84
D	PRO173
D	CYS174
D	GLY175

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 5

Chain	Residue
A	ARG180
D	ARG140
F	HOH5

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BU4 E 6

Chain	Residue
E	LEU189
E	ALA190
F	ARG194

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 4

Chain	Residue
C	ARG194
E	ALA88
E	ASN89
E	ARG116
E	HOH210
E	HOH231

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT E 9

Chain	Residue
C	ACT8
E	GLN90
E	HIS151
E	LYS155

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BU4 F 4

Chain	Residue
F	GLY175
F	ILE176

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BU4 G 3

Chain	Residue
G	PRO173
G	CYS174
G	GLY175
G	ILE176

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BU4 H 8

Chain	Residue
D	ARG194
H	LEU189
H	ALA190

---

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 H 1

Chain	Residue
B	ARG194
H	ALA88
H	ASN89
H	ARG116
H	HOH227
H	HOH228
H	HOH230
H	HOH246

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT H 6

Chain	Residue
B	ACT208
H	GLN90
H	HIS151
H	LYS155

---

Functional Information from PROSITE/UniProt

site_id	PS00319
Number of Residues	8
Details	APP_CUBD Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. GVEFVCCP

Chain	Residue	Details
A	GLY181-PRO188

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1288
Details	Domain: {"description":"E1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01217","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	760
Details	Region: {"description":"GFLD subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01217","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	464
Details	Region: {"description":"CuBD subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01217","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	112
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8158260","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01217","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17239395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25122912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FK1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01217","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17239395","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FK1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8344894","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Site: {"description":"Required for Cu(2+) reduction","evidences":[{"source":"PROSITE-ProRule","id":"PRU01217","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Site: {"description":"Cleavage; by caspases","evidences":[{"source":"PubMed","id":"10319819","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by CK2","evidences":[{"source":"PubMed","id":"8999878","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---