3KTM

Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Amyloid beta A4 protein	polymer	191	21762.1	8	UniProt (P05067) Pfam (PF02177) Pfam (PF12924)	Homo sapiens (human)	Alzheimer disease amyloid protein, ABPP, APP
2	I, J, M, P, R... (A, B, C, D, E...)	(3R)-butane-1,3-diol	non-polymer		90.1	8	Chemie (BU4)
3	K, N, Q, S, X (B, C, D, E, H)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
4	L, O, T, Y (B, C, E, H)	ACETATE ION	non-polymer		59.0	4	Chemie (ACT)
5	AA, BA, CA, DA, EA... (B, C, D, E, F...)	water	water		18.0	282	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 18 - 190 (UniProt: P05067)

PDB	External Database	Details
Met 17	-	initiating methionine
Ile 191	-	expression tag
Glu 192	-	expression tag
Gly 193	-	expression tag
Arg 194	-	expression tag
Lys 195	-	expression tag
Leu 196	-	expression tag
Ala 197	-	expression tag
Ala 198	-	expression tag
Ala 199	-	expression tag
Leu 200	-	expression tag
Glu 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
His 205	-	expression tag
His 206	-	expression tag
His 207	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	174096.6
Non-Polymers*	Number of molecules	17
	Total formula weight	1437.5
All*	Total formula weight	175534.1

*Water molecules are not included.