4OMD

X-ray structure of human furin in complex with the competitive inhibitor Phac-RVR-Amba

Summary for 4OMD

• Entry DOI: 10.2210/pdb4omd/pdb
• Related: 1P8J 4OMC
• Related PRD ID: PRD_001221
• Descriptor: Furin, phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine, FORMIC ACID, ... (6 entities in total)
• Functional Keywords: pro-protein convertase, serine protease, competitive inhibitor, protease-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P09958
• Total number of polymer chains: 12
• Total formula weight: 319732.33

Authors

Dahms, S.O.,Than, M.E. (deposition date: 2014-01-27, release date: 2014-04-09, Last modification date: 2014-05-28)

• Primary citation: Dahms, S.O.,Hardes, K.,Becker, G.L.,Steinmetzer, T.,Brandstetter, H.,Than, M.E.; X-ray Structures of Human Furin in Complex with Competitive Inhibitors.; Acs Chem.Biol., 9:1113-1118, 2014; PubMed: 24666235; DOI: 10.1021/cb500087x

Experimental method

X-RAY DIFFRACTION (2.7 Å)