4OMD

X-ray structure of human furin in complex with the competitive inhibitor Phac-RVR-Amba

Summary for 4OMD

Related4OMC 1P8J
Related PRD IDPRD_001221
DescriptorFurin, phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine, FORMIC ACID, ... (6 entities in total)
Functional Keywordspro-protein convertase, serine protease, competitive inhibitor, protease-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationGolgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein P09958
Total number of polymer chains12
Total molecular weight319732.33
Authors
Dahms, S.O.,Than, M.E. (deposition date: 2014-01-27, release date: 2014-04-09, Last modification date: 2014-05-28)
Primary citation
Dahms, S.O.,Hardes, K.,Becker, G.L.,Steinmetzer, T.,Brandstetter, H.,Than, M.E.
X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
Acs Chem.Biol., 9:1113-1118, 2014
PubMed: 24666235 (PDB entries with the same primary citation)
DOI: 10.1021/cb500087x
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21860.7%1.7%1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4omd
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Molmil generated image of 4omd
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Molmil generated image of 4omd
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More Biological unit images

Molmil generated image of 4omd
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Molmil generated image of 4omd
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Molmil generated image of 4omd
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4omd.pdb4.gz [83.45 KB])
Coordinate files for Biological unit (4omd.pdb2.gz [82.5 KB])
Coordinate files for Biological unit (4omd.pdb6.gz [82.8 KB])
Coordinate files for Biological unit (4omd.pdb5.gz [83.26 KB])
Coordinate files for Biological unit (4omd.pdb3.gz [82.79 KB])
Coordinate files for Biological unit (4omd.pdb1.gz [82.91 KB])