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4OMD

X-ray structure of human furin in complex with the competitive inhibitor Phac-RVR-Amba

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0006508biological_processproteolysis
A0008236molecular_functionserine-type peptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0006508biological_processproteolysis
B0008236molecular_functionserine-type peptidase activity
C0004252molecular_functionserine-type endopeptidase activity
C0006508biological_processproteolysis
C0008236molecular_functionserine-type peptidase activity
D0004252molecular_functionserine-type endopeptidase activity
D0006508biological_processproteolysis
D0008236molecular_functionserine-type peptidase activity
E0004252molecular_functionserine-type endopeptidase activity
E0006508biological_processproteolysis
E0008236molecular_functionserine-type peptidase activity
F0004252molecular_functionserine-type endopeptidase activity
F0006508biological_processproteolysis
F0008236molecular_functionserine-type peptidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE FMT A 601
ChainResidue
ATYR313
AGLN447
AFMT602
BGLN280

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FMT A 602
ChainResidue
BARG276
APHE275
ATYR313
ALYS449
ATYR571
AFMT601

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 603
ChainResidue
AASP115
AASP162
AVAL205
AASN208
AVAL210
AGLY212

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 604
ChainResidue
AASP258
AASP301
AGLU331
AHOH746
AHOH758
AHOH796

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 605
ChainResidue
AASP174
AASP179
AASP181
AHOH723
AHOH727
AHOH809

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NA A 606
ChainResidue
ATHR309
ASER311
ATHR314
AHOH764

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FMT B 601
ChainResidue
AARG276
AGLN280
BTYR313
BGLN447
BFMT602
BHOH742

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FMT B 602
ChainResidue
AARG276
BPHE275
BTYR313
BLYS449
BTYR571
BFMT601

site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 603
ChainResidue
BASP115
BASP162
BVAL205
BASN208
BVAL210
BGLY212

site_idBC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 604
ChainResidue
BASP258
BASP301
BGLU331
BHOH711
BHOH735
BHOH782

site_idBC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA B 605
ChainResidue
BASP174
BASP179
BASP181
BHOH769

site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NA B 606
ChainResidue
BTHR309
BSER311
BTHR314
BSER316
BHOH703

site_idBC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE FMT C 601
ChainResidue
CTYR313
CGLN447
CFMT602

site_idBC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FMT C 602
ChainResidue
CPHE275
CTYR313
CLYS449
CTYR571
CFMT601
DARG276

site_idBC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA C 603
ChainResidue
CASP115
CASP162
CVAL205
CASN208
CVAL210
CGLY212

site_idBC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA C 604
ChainResidue
CASP258
CASP301
CGLU331
CHOH725
CHOH742
CHOH769

site_idBC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA C 605
ChainResidue
CASP174
CASP179
CASP181
CHOH773

site_idBC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NA C 606
ChainResidue
CTHR309
CSER311
CTHR314
CHOH718

site_idCC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FMT D 601
ChainResidue
DHOH760
CARG276
CGLN280
DTYR313
DGLN447
DFMT602

site_idCC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FMT D 602
ChainResidue
CARG276
DPHE275
DTYR313
DLYS449
DTYR571
DFMT601

site_idCC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 603
ChainResidue
DASP115
DASP162
DVAL205
DASN208
DVAL210
DGLY212

site_idCC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 604
ChainResidue
DASP258
DASP301
DGLU331
DHOH710
DHOH725
DHOH797

site_idCC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA D 605
ChainResidue
DASP174
DASP179
DASP181
DHOH749
DHOH798

site_idCC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NA D 606
ChainResidue
DTHR309
DSER311
DTHR314
DHOH721

site_idCC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE FMT E 601
ChainResidue
ETYR313
EGLN447
EFMT602
EHOH740
FARG276

site_idCC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FMT E 602
ChainResidue
EPHE275
ETYR313
ELYS449
ETYR571
EFMT601
FARG276

site_idCC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA E 603
ChainResidue
EASP115
EASP162
EVAL205
EASN208
EVAL210
EGLY212

site_idDC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA E 604
ChainResidue
EASP258
EASP301
EGLU331
EHOH718
EHOH719
EHOH788

site_idDC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA E 605
ChainResidue
EASP174
EASP179
EASP181
EHOH789

site_idDC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NA E 606
ChainResidue
ETHR309
ESER311
ETHR314
EHOH704

site_idDC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE FMT F 601
ChainResidue
EARG276
FTYR313
FGLN447
FFMT602

site_idDC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FMT F 602
ChainResidue
EARG276
FPHE275
FTYR313
FLYS449
FTYR571
FFMT601

site_idDC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA F 603
ChainResidue
FASP115
FASP162
FVAL205
FASN208
FVAL210
FGLY212

site_idDC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA F 604
ChainResidue
FASP258
FASP301
FGLU331
FHOH704

site_idDC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA F 605
ChainResidue
FASP174
FASP179
FASP181
FHOH739
FHOH757
FHOH776

site_idDC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NA F 606
ChainResidue
FTHR309
FSER311
FTHR314
FHOH715

site_idEC1
Number of Residues22
DetailsBINDING SITE FOR CHAIN H OF PHENYLACETYL-ARG-VAL-ARG-(AMIDOMETHYL)BENZAMIDINE
ChainResidue
AASP154
AASP191
AASN192
AHIS194
AVAL231
AGLU236
ASER253
ATRP254
AGLY255
APRO256
AASP258
AASP264
AGLY265
AALA292
ASER293
AASN295
AASP306
ATYR308
ATHR367
ASER368
HHOH101
HHOH102

site_idEC2
Number of Residues24
DetailsBINDING SITE FOR CHAIN I OF PHENYLACETYL-ARG-VAL-ARG-(AMIDOMETHYL)BENZAMIDINE
ChainResidue
BASP154
BASP191
BASN192
BHIS194
BVAL231
BGLU236
BSER253
BTRP254
BGLY255
BPRO256
BASP258
BASP264
BGLY265
BALA292
BSER293
BGLY294
BASN295
BASP306
BTYR308
BTHR309
BTHR367
BSER368
IHOH101
IHOH102

site_idEC3
Number of Residues24
DetailsBINDING SITE FOR CHAIN J OF PHENYLACETYL-ARG-VAL-ARG-(AMIDOMETHYL)BENZAMIDINE
ChainResidue
CASP154
CASP191
CASN192
CHIS194
CVAL231
CGLU236
CSER253
CTRP254
CGLY255
CPRO256
CASP258
CASP264
CGLY265
CALA292
CSER293
CASN295
CASP306
CTYR308
CTHR309
CTHR367
CSER368
JHOH101
JHOH102
JHOH103

site_idEC4
Number of Residues23
DetailsBINDING SITE FOR CHAIN K OF PHENYLACETYL-ARG-VAL-ARG-(AMIDOMETHYL)BENZAMIDINE
ChainResidue
DASP154
DASP191
DASN192
DHIS194
DVAL231
DGLU236
DSER253
DTRP254
DGLY255
DPRO256
DASP258
DASP264
DGLY265
DALA292
DASN295
DASP306
DTYR308
DTHR309
DTHR367
DSER368
DHOH799
KHOH101
KHOH102

site_idEC5
Number of Residues23
DetailsBINDING SITE FOR CHAIN L OF PHENYLACETYL-ARG-VAL-ARG-(AMIDOMETHYL)BENZAMIDINE
ChainResidue
EASP154
EASP191
EASN192
EHIS194
EVAL231
EGLU236
ESER253
ETRP254
EGLY255
EPRO256
EASP258
EASP264
EGLY265
EALA292
EASN295
EASP306
ETYR308
ETHR309
ETHR367
ESER368
LHOH101
LHOH102
LHOH103

site_idEC6
Number of Residues26
DetailsBINDING SITE FOR CHAIN N OF PHENYLACETYL-ARG-VAL-ARG-(AMIDOMETHYL)BENZAMIDINE
ChainResidue
FASP154
FASP191
FASN192
FHIS194
FVAL231
FGLU236
FSER253
FTRP254
FGLY255
FPRO256
FASP258
FASP264
FGLY265
FALA292
FSER293
FGLY294
FASN295
FASP306
FTYR308
FTHR309
FTHR367
FSER368
FHOH704
FHOH770
NHOH101
NHOH102

Functional Information from PROSITE/UniProt
site_idPS00136
Number of Residues12
DetailsSUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VSILDDGIeknH
ChainResidueDetails
AVAL149-HIS160

site_idPS00137
Number of Residues11
DetailsSUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGTrCAGeVAA
ChainResidueDetails
AHIS194-ALA204

site_idPS00138
Number of Residues11
DetailsSUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSaSaPlAAG
ChainResidueDetails
AGLY366-GLY376

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240
ChainResidueDetails
AASP153
DASP153
DHIS194
DSER368
EASP153
EHIS194
ESER368
FASP153
FHIS194
FSER368
AHIS194
ASER368
BASP153
BHIS194
BSER368
CASP153
CHIS194
CSER368

site_idSWS_FT_FI2
Number of Residues72
DetailsBINDING: BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD
ChainResidueDetails
AASP115
AASP258
AASP301
AGLU331
BASP115
BASP162
BASP174
BASP179
BASP181
BVAL205
BASN208
AASP162
BVAL210
BGLY212
BASP258
BASP301
BGLU331
CASP115
CASP162
CASP174
CASP179
CASP181
AASP174
CVAL205
CASN208
CVAL210
CGLY212
CASP258
CASP301
CGLU331
DASP115
DASP162
DASP174
AASP179
DASP179
DASP181
DVAL205
DASN208
DVAL210
DGLY212
DASP258
DASP301
DGLU331
EASP115
AASP181
EASP162
EASP174
EASP179
EASP181
EVAL205
EASN208
EVAL210
EGLY212
EASP258
EASP301
AVAL205
EGLU331
FASP115
FASP162
FASP174
FASP179
FASP181
FVAL205
FASN208
FVAL210
FGLY212
AASN208
FASP258
FASP301
FGLU331
AVAL210
AGLY212

site_idSWS_FT_FI3
Number of Residues54
DetailsBINDING: BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD
ChainResidueDetails
AASP154
BASP154
BASP191
BGLU236
BSER253
BASP264
BALA292
BASP306
BTYR308
BSER368
CASP154
AASP191
CASP191
CGLU236
CSER253
CASP264
CALA292
CASP306
CTYR308
CSER368
DASP154
DASP191
AGLU236
DGLU236
DSER253
DASP264
DALA292
DASP306
DTYR308
DSER368
EASP154
EASP191
EGLU236
ASER253
ESER253
EASP264
EALA292
EASP306
ETYR308
ESER368
FASP154
FASP191
FGLU236
FSER253
AASP264
FASP264
FALA292
FASP306
FTYR308
FSER368
AALA292
AASP306
ATYR308
ASER368

site_idSWS_FT_FI4
Number of Residues18
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN387
DASN387
DASN440
DASN553
EASN387
EASN440
EASN553
FASN387
FASN440
FASN553
AASN440
AASN553
BASN387
BASN440
BASN553
CASN387
CASN440
CASN553

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PDB entries from 2024-03-27

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