4OMC

X-ray structure of human furin in complex with the competitive inhibitor meta-guanidinomethyl-Phac-RVR-Amba

Summary for 4OMC

Related4OMD 1P8J
Related PRD IDPRD_001220
DescriptorFurin, meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine, FORMIC ACID, ... (6 entities in total)
Functional Keywordspro-protein convertase, serine protease, competitive inhibitor, protease-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationGolgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein P09958
Total number of polymer chains12
Total molecular weight320711.11
Authors
Dahms, S.O.,Than, M.E. (deposition date: 2014-01-27, release date: 2014-04-09, Last modification date: 2014-05-28)
Primary citation
Dahms, S.O.,Hardes, K.,Becker, G.L.,Steinmetzer, T.,Brandstetter, H.,Than, M.E.
X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
Acs Chem.Biol., 9:1113-1118, 2014
PubMed: 24666235 (PDB entries with the same primary citation)
DOI: 10.1021/cb500087x
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.217502.6%2.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 4omc
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Molmil generated image of 4omc
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4omc.pdb4.gz [86.14 KB])
Coordinate files for Biological unit (4omc.pdb5.gz [86.07 KB])
Coordinate files for Biological unit (4omc.pdb2.gz [85.67 KB])
Coordinate files for Biological unit (4omc.pdb3.gz [85.98 KB])
Coordinate files for Biological unit (4omc.pdb1.gz [86.18 KB])
Coordinate files for Biological unit (4omc.pdb6.gz [85.66 KB])