4OMC

X-ray structure of human furin in complex with the competitive inhibitor meta-guanidinomethyl-Phac-RVR-Amba

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Furin	polymer	482	52388.6	6	UniProt (P09958) Pfam (PF00082) Pfam (PF01483) In PDB	Homo sapiens (human)	Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, PACE
2	H, I, J, K, L...	meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine	polymer	5	735.9	6	BIRD (PRD_001220)
3	F, C, D, A, E...	FORMIC ACID	non-polymer		46.0	24	Chemie (FMT)
4	B, F, C, D, A...	CALCIUM ION	non-polymer		40.1	18	Chemie (CA)
5	B, F, C, D, A...	SODIUM ION	non-polymer		23.0	6	Chemie (NA)
6		water	water		18.0	1346	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 108 - 574 (UniProt: P09958)

PDB	External Database	Details
Ser 575	-	EXPRESSION TAG
Gly 576	-	EXPRESSION TAG
Ser 577	-	EXPRESSION TAG
Leu 578	-	EXPRESSION TAG
Val 579	-	EXPRESSION TAG
Pro 580	-	EXPRESSION TAG
Arg 581	-	EXPRESSION TAG
Gly 582	-	EXPRESSION TAG
Ser 583	-	EXPRESSION TAG
His 584	-	EXPRESSION TAG
His 585	-	EXPRESSION TAG
His 586	-	EXPRESSION TAG
His 587	-	EXPRESSION TAG
His 588	-	EXPRESSION TAG
His 589	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	318747.2
Non-Polymers*	Number of molecules	48
	Total formula weight	1963.9
All*	Total formula weight	320711.1

*Water molecules are not included.