X-ray structure of the proprotein convertase furin bound with the competitive inhibitor Arg-Arg-Arg-Val-Arg-Amba

Summary for 6EQX

DescriptorFurin, Arg-Arg-Arg-Val-Arg-00S, CALCIUM ION, ... (6 entities in total)
Functional Keywordsprotease, inhibitor, proprotein convertase, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationGolgi apparatus, trans-Golgi network membrane ; Single- pass type I membrane protein  P09958
Total number of polymer chains2
Total molecular weight53513.35
Dahms, S.O.,Than, M.E. (deposition date: 2017-10-16, release date: 2018-02-28)
Primary citation
Dahms, S.O.,Hardes, K.,Steinmetzer, T.,Than, M.E.
X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry, 57:925-934, 2018
PubMed: 29314830 (PDB entries with the same primary citation)
DOI: 10.1021/acs.biochem.7b01124
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.183101.3%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution