6EQX
X-ray structure of the proprotein convertase furin bound with the competitive inhibitor Arg-Arg-Arg-Val-Arg-Amba
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Furin | polymer | 482 | 52388.6 | 1 | UniProt (P09958) Pfam (PF00082) Pfam (PF01483) | Homo sapiens (Human) | Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE |
| 2 | B (D) | Arg-Arg-Arg-Val-Arg-00S | polymer | 6 | 877.1 | 1 | synthetic construct | ||
| 3 | C, D, E (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 4 | F, G, H, I (A) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 5 | J (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | K, L (A, D) | water | water | 18.0 | 471 | Chemie (HOH) |
Sequence modifications
A: 108 - 567 (UniProt: P09958)
| PDB | External Database | Details |
|---|---|---|
| Leu 568 | - | expression tag |
| Val 569 | - | expression tag |
| Leu 570 | - | expression tag |
| Tyr 571 | - | expression tag |
| Gly 572 | - | expression tag |
| Thr 573 | - | expression tag |
| Ala 574 | - | expression tag |
| Ser 575 | - | expression tag |
| Gly 576 | - | expression tag |
| Ser 577 | - | expression tag |
| Leu 578 | - | expression tag |
| Val 579 | - | expression tag |
| Pro 580 | - | expression tag |
| Arg 581 | - | expression tag |
| Gly 582 | - | expression tag |
| Ser 583 | - | expression tag |
| His 584 | - | expression tag |
| His 585 | - | expression tag |
| His 586 | - | expression tag |
| His 587 | - | expression tag |
| His 588 | - | expression tag |
| His 589 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53265.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 247.6 | |
| All* | Total formula weight | 53513.3 |
