5JMR

X-ray structure of the furin inhibitory antibody Nb14

Summary for 5JMR

Descriptorcamelid VHH fragment, CHLORIDE ION (3 entities in total)
Functional Keywordscamelid, antibody, inhibitor, furin, immune system
Biological sourceCamelus dromedarius (dromedary)
Total number of polymer chains2
Total molecular weight27363.22
Authors
Dahms, S.O.,Than, M.E. (deposition date: 2016-04-29, release date: 2016-12-07, Last modification date: 2019-10-16)
Primary citation
Dahms, S.O.,Creemers, J.W.,Schaub, Y.,Bourenkov, G.P.,Zogg, T.,Brandstetter, H.,Than, M.E.
The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
Sci Rep, 6:34303-34303, 2016
PubMed: 27670069 (PDB entries with the same primary citation)
DOI: 10.1038/srep34303
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.27 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21930 5.3% 3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution