5JXG

Structure of the unliganded form of the proprotein convertase furin.

Summary for 5JXG

DescriptorFurin, CALCIUM ION, SODIUM ION, ... (5 entities in total)
Functional Keywordsprotease, apo-structure, proteolysis, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationGolgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein P09958
Total number of polymer chains1
Total molecular weight52728.21
Authors
Dahms, S.O.,Arciniega, M.,Steinmetzer, T.,Huber, R.,Than, M.E. (deposition date: 2016-05-13, release date: 2016-10-05, Last modification date: 2016-10-19)
Primary citation
Dahms, S.O.,Arciniega, M.,Steinmetzer, T.,Huber, R.,Than, M.E.
Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113:11196-11201, 2016
PubMed: 27647913 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1613630113
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.17510.2%1.6%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution