5JXG

Structure of the unliganded form of the proprotein convertase furin.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 601

Chain	Residue
A	ASP174
A	ASP179
A	ASP181
A	HOH751
A	HOH786
A	HOH1187

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 602

Chain	Residue
A	ASN208
A	VAL210
A	GLY212
A	ASP115
A	ASP162
A	VAL205

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 603

Chain	Residue
A	ASP258
A	ASP301
A	GLU331
A	HOH838
A	HOH991
A	HOH1110

---

site_id	AC4
Number of Residues	5
Details	binding site for residue NA A 604

Chain	Residue
A	THR309
A	SER311
A	THR314
A	SER316
A	HOH871

---

site_id	AC5
Number of Residues	8
Details	binding site for residue NA A 605

Chain	Residue
A	ASP264
A	GLY265
A	NA606
A	NA610
A	HOH824
A	HOH874
A	HOH1175
A	HOH1242

---

site_id	AC6
Number of Residues	7
Details	binding site for residue NA A 606

Chain	Residue
A	NA605
A	HOH824
A	HOH874
A	HOH928
A	HOH1242
A	HOH1278
A	HOH1304

---

site_id	AC7
Number of Residues	7
Details	binding site for residue NA A 607

Chain	Residue
A	SER279
A	GLY284
A	HOH733
A	HOH765
A	HOH1008
A	HOH1213
A	HOH1244

---

site_id	AC8
Number of Residues	4
Details	binding site for residue NA A 608

Chain	Residue
A	SER544
A	SER544
A	HOH823
A	HOH823

---

site_id	AC9
Number of Residues	6
Details	binding site for residue NA A 609

Chain	Residue
A	GLU546
A	GLU546
A	HOH1063
A	HOH1063
A	HOH1177
A	HOH1177

---

site_id	AD1
Number of Residues	6
Details	binding site for residue NA A 610

Chain	Residue
A	ASP264
A	NA605
A	HOH850
A	HOH1168
A	HOH1175
A	HOH1239

---

site_id	AD2
Number of Residues	6
Details	binding site for residue NA A 611

Chain	Residue
A	THR413
A	HOH840
A	HOH907
A	HOH947
A	HOH1173
A	HOH1289

---

site_id	AD3
Number of Residues	4
Details	binding site for residue CL A 612

Chain	Residue
A	ARG276
A	TYR313
A	LYS449
A	TYR571

---

Functional Information from PROSITE/UniProt

site_id	PS00136
Number of Residues	12
Details	SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VSILDDGIeknH

Chain	Residue	Details
A	VAL149-HIS160

---

site_id	PS00137
Number of Residues	11
Details	SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGTrCAGeVAA

Chain	Residue	Details
A	HIS194-ALA204

---

site_id	PS00138
Number of Residues	11
Details	SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSaSaPlAAG

Chain	Residue	Details
A	GLY366-GLY376

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240

Chain	Residue	Details
A	ASP153
A	HIS194
A	SER368

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD

Chain	Residue	Details
A	ASP115
A	ASP258
A	ASP301
A	GLU331
A	ASP162
A	ASP174
A	ASP179
A	ASP181
A	VAL205
A	ASN208
A	VAL210
A	GLY212

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	BINDING: BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD

Chain	Residue	Details
A	ASP154
A	ASP191
A	GLU236
A	SER253
A	ASP264
A	ALA292
A	ASP306
A	TYR308
A	SER368

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN387
A	ASN440
A	ASN553

---