7QY1
X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 4
Summary for 7QY1
Entry DOI | 10.2210/pdb7qy1/pdb |
Descriptor | Furin, 3-[4-[5-[4-[[4-(acetamidomethyl)piperidin-1-ium-1-yl]methyl]-6-[3,5-bis(chloranyl)phenyl]pyridin-2-yl]oxypyridin-2-yl]piperazin-1-ium-1-yl]propanoate, CALCIUM ION, ... (8 entities in total) |
Functional Keywords | proprotein convertase, inhibitor, sars-cov-2, protease, complex, furin, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 53770.69 |
Authors | Dahms, S.O.,Brandstetter, H.,Pautsch, A. (deposition date: 2022-01-27, release date: 2022-04-20, Last modification date: 2024-01-31) |
Primary citation | Dahms, S.O.,Schnapp, G.,Winter, M.,Buttner, F.H.,Schleputz, M.,Gnamm, C.,Pautsch, A.,Brandstetter, H. Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17:816-821, 2022 Cited by PubMed: 35377598DOI: 10.1021/acschembio.2c00103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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