7RZF
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![BU of 7rzf by Molmil](/molmil-images/mine/7rzf) | Insulin Degrading Enzyme O/pC | 分子名称: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | 登録日 | 2021-08-27 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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7RZG
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![BU of 7rzg by Molmil](/molmil-images/mine/7rzg) | Insulin Degrading Enzyme O/pO | 分子名称: | Cysteine-free Insulin-degrading enzyme | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | 登録日 | 2021-08-27 | 公開日 | 2022-08-31 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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7V29
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![BU of 7v29 by Molmil](/molmil-images/mine/7v29) | Crystal structure of FGFR4 with a dual-warhead covalent inhhibitor | 分子名称: | Fibroblast growth factor receptor 4, N-[2-[[3-(3,5-dimethoxyphenyl)-2-oxidanylidene-1-[3-(4-propanoylpiperazin-1-yl)propyl]-4H-pyrimido[4,5-d]pyrimidin-7-yl]amino]phenyl]propanamide, SULFATE ION | 著者 | Chen, X.J, Jiang, L.Y, Dai, S.Y, Qu, L.Z, Chen, Y.H. | 登録日 | 2021-08-07 | 公開日 | 2022-03-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.983 Å) | 主引用文献 | Structure-based design of a dual-warhead covalent inhibitor of FGFR4. Commun Chem, 5, 2022
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8JOT
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![BU of 8jot by Molmil](/molmil-images/mine/8jot) | Crystal structure of CSF-1R kinase domain with sulfatinib | 分子名称: | GLYCEROL, Macrophage colony-stimulating factor 1 receptor, N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide | 著者 | Lin, Q.M, Chen, X.J, Chen, Y.H. | 登録日 | 2023-06-08 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R. Commun Chem, 7, 2024
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8JMZ
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![BU of 8jmz by Molmil](/molmil-images/mine/8jmz) | FGFR1 kinase domain with sulfatinib | 分子名称: | Fibroblast growth factor receptor 1, GLYCEROL, N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide, ... | 著者 | Chen, X.J, Lin, Q.M, Chen, Y.H. | 登録日 | 2023-06-05 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.988 Å) | 主引用文献 | Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R. Commun Chem, 7, 2024
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5XN3
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![BU of 5xn3 by Molmil](/molmil-images/mine/5xn3) | |
5Y14
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![BU of 5y14 by Molmil](/molmil-images/mine/5y14) | Crystal structure of LP-40/N44 | 分子名称: | LP-40, N44 | 著者 | Zhang, X, Wang, X, He, Y. | 登録日 | 2017-07-19 | 公開日 | 2017-11-08 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.762 Å) | 主引用文献 | Enfuvirtide (T20)-Based Lipopeptide Is a Potent HIV-1 Cell Fusion Inhibitor: Implications for Viral Entry and Inhibition J. Virol., 91, 2017
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7CDA
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![BU of 7cda by Molmil](/molmil-images/mine/7cda) | Crystal structure of T2R-TTL-PAC complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | 登録日 | 2020-06-19 | 公開日 | 2021-06-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.659 Å) | 主引用文献 | Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond. J.Med.Chem., 65, 2022
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7CE8
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![BU of 7ce8 by Molmil](/molmil-images/mine/7ce8) | Crystal structure of T2R-TTL-Compound11 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | 登録日 | 2020-06-22 | 公開日 | 2021-06-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.725 Å) | 主引用文献 | Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond. J.Med.Chem., 65, 2022
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7CEK
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![BU of 7cek by Molmil](/molmil-images/mine/7cek) | Crystal structure of T2R-TTL-BML-284 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | 著者 | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | 登録日 | 2020-06-23 | 公開日 | 2021-06-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.696 Å) | 主引用文献 | Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond. J.Med.Chem., 65, 2022
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7CE6
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![BU of 7ce6 by Molmil](/molmil-images/mine/7ce6) | Crystal structure of T2R-TTL-Compound9 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | 登録日 | 2020-06-22 | 公開日 | 2021-06-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.695 Å) | 主引用文献 | Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond. J.Med.Chem., 65, 2022
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7CLD
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![BU of 7cld by Molmil](/molmil-images/mine/7cld) | Crystal structure of T2R-TTL-Cevipabulin complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, CALCIUM ION, ... | 著者 | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | 登録日 | 2020-07-20 | 公開日 | 2021-07-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.611 Å) | 主引用文献 | Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect. Sci Adv, 7, 2021
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7DP8
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![BU of 7dp8 by Molmil](/molmil-images/mine/7dp8) | Crystal structure of T2R-TTL-Cevipabulin-eribulin complex | 分子名称: | (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]hentetracontan-24-one (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ... | 著者 | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | 登録日 | 2020-12-18 | 公開日 | 2021-07-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.446 Å) | 主引用文献 | Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect. Sci Adv, 7, 2021
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8WD0
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![BU of 8wd0 by Molmil](/molmil-images/mine/8wd0) | Crystal structure of T2R-TTL-Erianin complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol, CALCIUM ION, ... | 著者 | Yang, J. | 登録日 | 2023-09-14 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The cytotoxic natural compound erianin binds to colchicine site of beta-tubulin and overcomes taxane resistance Bioorg.Chem., 150, 2024
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6M2Z
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![BU of 6m2z by Molmil](/molmil-images/mine/6m2z) | Crystal structure of a formolase, BFD variant M3 from Pseudomonas putida | 分子名称: | Benzoylformate decarboxylase, MAGNESIUM ION, THIAMINE DIPHOSPHATE | 著者 | Wei, H.L, Liu, W.D, Li, T.Z, Zhu, L.L. | 登録日 | 2020-03-02 | 公開日 | 2021-03-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Totally atom-economical synthesis of lactic acid from formaldehyde: combined bio-carboligation and chemo-rearrangement without the isolation of intermediate. Green Chem, 22, 2020
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6M2Y
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![BU of 6m2y by Molmil](/molmil-images/mine/6m2y) | Crystal structure of a formolase, BFD variant M6 from Pseudomonas putida | 分子名称: | Benzoylformate decarboxylase, MAGNESIUM ION, THIAMINE DIPHOSPHATE | 著者 | Wei, H.L, Liu, W.D, Li, T.Z, Zhu, L.L. | 登録日 | 2020-03-02 | 公開日 | 2021-03-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Totally atom-economical synthesis of lactic acid from formaldehyde: combined bio-carboligation and chemo-rearrangement without the isolation of intermediate. Green Chem, 22, 2020
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8J54
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![BU of 8j54 by Molmil](/molmil-images/mine/8j54) | Crystal structure of RXR/DR2 complex | 分子名称: | DNA (5'-D(*CP*AP*TP*GP*AP*CP*CP*TP*AP*CP*TP*GP*AP*CP*CP*TP*AP*G)-3'), DNA (5'-D(*CP*TP*AP*GP*GP*TP*CP*AP*GP*TP*AP*GP*GP*TP*CP*AP*TP*G)-3'), Retinoic acid receptor RXR, ... | 著者 | Chen, Y, Jiang, L. | 登録日 | 2023-04-21 | 公開日 | 2024-01-17 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Structural characterization of the DNA binding mechanism of retinoic acid-related orphan receptor gamma. Structure, 32, 2024
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7VUE
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![BU of 7vue by Molmil](/molmil-images/mine/7vue) | Structural insight of the molecular mechanism of cilofexor bound to FXR | 分子名称: | 2-[3-[4-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-2-chloranyl-phenyl]-3-oxidanyl-azetidin-1-yl]pyridine-4-carboxylic acid, Bile acid receptor, Peptide from Nuclear receptor coactivator 2 | 著者 | Jiang, L, Chen, Y.C. | 登録日 | 2021-11-02 | 公開日 | 2022-03-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor. Biochem.Biophys.Res.Commun., 595, 2022
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7VNI
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![BU of 7vni by Molmil](/molmil-images/mine/7vni) | AHR-ARNT PAS-B heterodimer | 分子名称: | Ahr homolog spineless, Aryl hydrocarbon receptor nuclear translocator, SULFATE ION | 著者 | Dai, S.Y. | 登録日 | 2021-10-11 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun, 13, 2022
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7VNA
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![BU of 7vna by Molmil](/molmil-images/mine/7vna) | drosophlia AHR PAS-B domain | 分子名称: | Ahr homolog spineless | 著者 | Dai, S.Y. | 登録日 | 2021-10-10 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.597 Å) | 主引用文献 | Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun, 13, 2022
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7VNH
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7WF5
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![BU of 7wf5 by Molmil](/molmil-images/mine/7wf5) | c-Src in complex with ponatinib | 分子名称: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, Proto-oncogene tyrosine-protein kinase Src | 著者 | Guo, M, Duan, Y, Dai, S, Chen, X, Chen, Y. | 登録日 | 2021-12-26 | 公開日 | 2022-03-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | Structural study of ponatinib in inhibiting SRC kinase. Biochem.Biophys.Res.Commun., 598, 2022
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5WOB
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![BU of 5wob by Molmil](/molmil-images/mine/5wob) | Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin | 分子名称: | IDE-bound Fab heavy chain, IDE-bound Fab light chain, Insulin, ... | 著者 | McCord, L.A, Liang, W.G, Farcasanu, M, Wang, A.G, Koide, S, Tang, W.J. | 登録日 | 2017-08-01 | 公開日 | 2018-04-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.95 Å) | 主引用文献 | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
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7XDR
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![BU of 7xdr by Molmil](/molmil-images/mine/7xdr) | Crystal structure of a glucosylglycerol phosphorylase from Marinobacter adhaerens | 分子名称: | Glucosylglycerol phosphorylase | 著者 | Wei, H.L, Li, Q, Yang, J.G, Liu, W.D, Sun, Y.X. | 登録日 | 2022-03-28 | 公開日 | 2023-02-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Protein Engineering of Glucosylglycerol Phosphorylase Facilitating Efficient and Highly Regio- and Stereoselective Glycosylation of Polyols in a Synthetic System. Acs Catalysis, 2022
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5TKK
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![BU of 5tkk by Molmil](/molmil-images/mine/5tkk) | |