7WF5

c-Src in complex with ponatinib

Summary for 7WF5

• Entry DOI: 10.2210/pdb7wf5/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide (3 entities in total)
• Functional Keywords: inhibitor, kinase, oncoprotein
• Biological source: Gallus gallus (chicken)
• Total number of polymer chains: 2
• Total formula weight: 66518.41

Authors

Guo, M.,Duan, Y.,Dai, S.,Chen, X.,Chen, Y. (deposition date: 2021-12-26, release date: 2022-03-02, Last modification date: 2023-11-29)

• Primary citation: Guo, M.,Duan, Y.,Dai, S.,Li, J.,Chen, X.,Qu, L.,Chen, Z.,Wei, H.,Jiang, L.,Chen, Y.; Structural study of ponatinib in inhibiting SRC kinase.; Biochem.Biophys.Res.Commun., 598:15-19, 2022; PubMed: 35151199; DOI: 10.1016/j.bbrc.2022.02.001

Experimental method

X-RAY DIFFRACTION (1.798 Å)