7DP8

Crystal structure of T2R-TTL-Cevipabulin-eribulin complex

Summary for 7DP8

• Entry DOI: 10.2210/pdb7dp8/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ... (14 entities in total)
• Functional Keywords: tubulin inhibitor, tublin, structural protein
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 6
• Total formula weight: 266223.88

Authors

Chen, L.J.,Chen, Q.,Yu, Y.,Yang, J.H. (deposition date: 2020-12-18, release date: 2021-07-07, Last modification date: 2023-11-29)

• Primary citation: Yang, J.,Yu, Y.,Li, Y.,Yan, W.,Ye, H.,Niu, L.,Tang, M.,Wang, Z.,Yang, Z.,Pei, H.,Wei, H.,Zhao, M.,Wen, J.,Yang, L.,Ouyang, L.,Wei, Y.,Chen, Q.,Li, W.,Chen, L.; Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect.; Sci Adv, 7:-, 2021; PubMed: 34138737; DOI: 10.1126/sciadv.abg4168

Experimental method

X-RAY DIFFRACTION (2.446 Å)