8WD0

Crystal structure of T2R-TTL-Erianin complex

Summary for 8WD0

• Entry DOI: 10.2210/pdb8wd0/pdb
• Descriptor: Tubulin alpha-1B chain, 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol, GUANOSINE-5'-DIPHOSPHATE, ... (13 entities in total)
• Functional Keywords: microtubule, cell cycle
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 269979.26

Authors

Yang, J. (deposition date: 2023-09-14, release date: 2024-07-03)

• Primary citation: Yan, W.,Zhou, Y.,Yuan, X.,Bai, P.,Tang, M.,Chen, L.,Wei, H.,Yang, J.; The cytotoxic natural compound erianin binds to colchicine site of beta-tubulin and overcomes taxane resistance; Bioorg.Chem., 150:107569-, 2024; PubMed: 38905886; DOI: 10.1016/j.bioorg.2024.107569

Experimental method

X-RAY DIFFRACTION (2.6 Å)