7CE6

Crystal structure of T2R-TTL-Compound9 complex

Summary for 7CE6

Entry DOI	10.2210/pdb7ce6/pdb
Descriptor	Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N-benzyl-9H-beta-carbolin-3-amine, ... (13 entities in total)
Functional Keywords	tubulin inhibitor, tublin, structural protein
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	6
Total formula weight	264834.30
Authors	Chen, L.J.,Chen, Q.,Yu, Y.,Yang, J.H. (deposition date: 2020-06-22, release date: 2021-06-30, Last modification date: 2023-11-29)
Primary citation	Yang, J.,Li, Y.,Qiu, Q.,Wang, R.,Yan, W.,Yu, Y.,Niu, L.,Pei, H.,Wei, H.,Ouyang, L.,Ye, H.,Xu, D.,Wei, Y.,Chen, Q.,Chen, L. Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond. J.Med.Chem., 65:9159-9173, 2022 Cited by PubMed: 35762925 DOI: 10.1021/acs.jmedchem.2c00379 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.695 Å)

Structure validation