5XN3

Crystal structure of SPSB2 in complex with a rational designed RGD containing cyclic peptide inhibitor of SPSB2-iNOS interaction

Summary for 5XN3

• Entry DOI: 10.2210/pdb5xn3/pdb
• Related PRD ID: PRD_002275
• Descriptor: SPRY domain-containing SOCS box protein 2, cR8 peptide from NOS2 (3 entities in total)
• Functional Keywords: e3 ubiquitin, ligase, cyclic peptide inhibitor, spry domain-containing, socs box protein, inducible nitric oxide synthase, nitric oxide, protein binding-inhibitor complex, protein binding/inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : Q99619
• Total number of polymer chains: 2
• Total formula weight: 23798.55

Authors

You, T.,Kuang, Z. (deposition date: 2017-05-17, release date: 2017-06-14, Last modification date: 2023-11-22)

• Primary citation: You, T.,Wang, Y.,Li, K.,Zhang, D.,Wei, H.,Luo, Y.,Li, H.,Lu, Y.,Su, X.,Kuang, Z.; Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction.; Biochem. Biophys. Res. Commun., 489:346-352, 2017; PubMed: 28549582; DOI: 10.1016/j.bbrc.2017.05.122

Experimental method

X-RAY DIFFRACTION (1.34 Å)