5XN3

Crystal structure of SPSB2 in complex with a rational designed RGD containing cyclic peptide inhibitor of SPSB2-iNOS interaction

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	SPRY domain-containing SOCS box protein 2	polymer	209	22896.6	1	UniProt (Q99619) Pfam (PF00622) In PDB	Homo sapiens (Human)	SSB-2,Gene-rich cluster protein C9
2	B	cR8 peptide from NOS2	polymer	8	901.9	1	UniProt (by SIFTS) (P35228) In PDB BIRD (PRD_002275)	Homo sapiens
3		water	water		18.0	54	Chemie (HOH)

Sequence modifications

A: 22 - 220 (UniProt: Q99619)

PDB	External Database	Details
Met 20	-	cloning artifact
Gly 21	-	cloning artifact
Gly 221	-	expression tag
Ser 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag
His 228	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	23798.5
All*	Total formula weight	23798.5

*Water molecules are not included.