4GP0
| The crystal structure of human fascin 1 R149A K150A R151A mutant | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BROMIDE ION, ... | 著者 | Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y. | 登録日 | 2012-08-20 | 公開日 | 2012-11-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular mechanism of fascin function in filopodial formation. J.Biol.Chem., 288, 2013
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4GOV
| The crystal structure of human fascin 1 S39D mutant | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, BROMIDE ION, CHLORIDE ION, ... | 著者 | Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y. | 登録日 | 2012-08-20 | 公開日 | 2012-11-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Molecular mechanism of fascin function in filopodial formation. J.Biol.Chem., 288, 2013
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6DFN
| Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa | 分子名称: | (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, (8S)-8-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-1,8-dihydro-2H-[1]benzopyrano[4,3-d][1]benzoxepine-5,11-diol, Estrogen receptor, ... | 著者 | Kiefer, J.R, Vinogradova, M, Liang, J, Zhang, B, Ortwine, D.F, Nettles, K.W, Nwachukwu, J.C. | 登録日 | 2018-05-15 | 公開日 | 2019-02-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Bioorg. Med. Chem. Lett., 29, 2019
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4GOY
| The crystal structure of human fascin 1 K41A mutant | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, BROMIDE ION, CHLORIDE ION, ... | 著者 | Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y. | 登録日 | 2012-08-20 | 公開日 | 2012-11-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular mechanism of fascin function in filopodial formation. J.Biol.Chem., 288, 2013
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3EB7
| Crystal Structure of Insecticidal Delta-Endotoxin Cry8Ea1 from Bacillus Thuringiensis at 2.2 Angstroms Resolution | 分子名称: | ACETATE ION, Insecticidal Delta-Endotoxin Cry8Ea1, SULFATE ION | 著者 | Guo, S, Ye, S, Song, F, Zhang, J, Wei, L, Shu, C.L. | 登録日 | 2008-08-27 | 公開日 | 2008-09-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of Bacillus thuringiensis Cry8Ea1: An insecticidal toxin toxic to underground pests, the larvae of Holotrichia parallela. J.Struct.Biol., 168, 2009
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8I2H
| Follicle stimulating hormone receptor | 分子名称: | Follicle-stimulating hormone receptor | 著者 | Duan, J, Xu, P, Yang, J, Ji, Y, Zhang, H, Mao, C, Luan, X, Jiang, Y, Zhang, Y, Zhang, S, Xu, H.E. | 登録日 | 2023-01-14 | 公開日 | 2023-03-22 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (6 Å) | 主引用文献 | Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nat Commun, 14, 2023
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8I2G
| FSHR-Follicle stimulating hormone-compound 716340-Gs complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Duan, J, Xu, P, Yang, J, Ji, Y, Zhang, H, Mao, C, Luan, X, Jiang, Y, Zhang, Y, Zhang, S, Xu, H.E. | 登録日 | 2023-01-14 | 公開日 | 2023-03-29 | 最終更新日 | 2023-04-05 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nat Commun, 14, 2023
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3MTS
| Chromo Domain of Human Histone-Lysine N-Methyltransferase SUV39H1 | 分子名称: | Histone-lysine N-methyltransferase SUV39H1 | 著者 | Lam, R, Li, Z, Wang, J, Crombet, L, Walker, J.R, Ouyang, H, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2010-04-30 | 公開日 | 2010-06-30 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3. Plos One, 7, 2012
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3NFS
| Crystal structure the Fab fragment of therapeutic antibody daclizumab | 分子名称: | Heavy chain of Fab fragment of daclizumab, Light chain of Fab fragment of daclizumab | 著者 | Yang, H, Wang, J, Du, J, Zhong, C, Guo, Y, Ding, J. | 登録日 | 2010-06-10 | 公開日 | 2010-09-15 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis of immunosuppression by the therapeutic antibody daclizumab Cell Res., 20, 2010
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3NFP
| Crystal structure of the Fab fragment of therapeutic antibody daclizumab in complex with IL-2Ra (CD25) ectodomain | 分子名称: | Heavy chain of Fab fragment of daclizumab, Interleukin-2 receptor subunit alpha, Light chain of Fab fragment of daclizumab | 著者 | Yang, H, Wang, J, Du, J, Zhong, C, Guo, Y, Ding, J. | 登録日 | 2010-06-10 | 公開日 | 2010-09-15 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Structural basis of immunosuppression by the therapeutic antibody daclizumab Cell Res., 20, 2010
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8TOB
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8TV9
| Inner Mat-T4P complex | 分子名称: | Fimbrial protein, Maturation protein | 著者 | Meng, R, Xing, Z, Thongchol, J, Zhang, J. | 登録日 | 2023-08-17 | 公開日 | 2024-03-06 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (8.15 Å) | 主引用文献 | Structural basis of Acinetobacter type IV pili targeting by an RNA virus. Nat Commun, 15, 2024
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8TWC
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8TVA
| Outer Mat-T4P complex | 分子名称: | Fimbrial protein, Maturation protein | 著者 | Meng, R, Xing, Z, Thongchol, J, Zhang, J. | 登録日 | 2023-08-17 | 公開日 | 2024-03-06 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (8.55 Å) | 主引用文献 | Structural basis of Acinetobacter type IV pili targeting by an RNA virus. Nat Commun, 15, 2024
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6POM
| Cryo-EM structure of the full-length Bacillus subtilis glyQS T-box riboswitch in complex with tRNA-Gly | 分子名称: | T-box GlyQS leader (155-MER), tRNAGly (75-MER) | 著者 | Li, S, Su, Z, Zhang, J, Chiu, W. | 登録日 | 2019-07-04 | 公開日 | 2019-11-20 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions. Nat.Struct.Mol.Biol., 26, 2019
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8TW2
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5GXO
| Discovery of a compound that activates SIRT3 to deacetylate Manganese Superoxide Dismutase | 分子名称: | MANGANESE (II) ION, Superoxide dismutase [Mn], mitochondrial | 著者 | Lu, J, Li, J, Wu, M, Wang, J, Xia, Q. | 登録日 | 2016-09-19 | 公開日 | 2017-08-09 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase. Free Radic. Biol. Med., 112, 2017
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5CA1
| Crystal structure of T2R-TTL-Nocodazole complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Wang, Y, Yu, Y, Chen, Q, Yang, J. | 登録日 | 2015-06-29 | 公開日 | 2015-11-04 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. Febs J., 283, 2016
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5C8Y
| Crystal structure of T2R-TTL-Plinabulin complex | 分子名称: | (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wang, Y, Yu, Y, Chen, Q, Yang, J. | 登録日 | 2015-06-26 | 公開日 | 2015-11-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.594 Å) | 主引用文献 | Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. Febs J., 283, 2016
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7TOB
| Crystal structure of the SARS-CoV-2 Omicron main protease (Mpro) in complex with inhibitor GC376 | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5, DI(HYDROXYETHYL)ETHER | 著者 | Sacco, M.D, Wang, J, Chen, Y. | 登録日 | 2022-01-24 | 公開日 | 2022-02-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition. Cell Res., 32, 2022
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5CA0
| Crystal structure of T2R-TTL-Lexibulin complex | 分子名称: | 1-ethyl-3-[2-methoxy-4-(5-methyl-4-{[(1S)-1-(pyridin-3-yl)butyl]amino}pyrimidin-2-yl)phenyl]urea, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wang, Y, Yu, Y, Chen, Q, Yang, J. | 登録日 | 2015-06-29 | 公開日 | 2015-11-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. Febs J., 283, 2016
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5CB4
| Crystal structure of T2R-TTL-Tivantinib complex | 分子名称: | (3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wang, Y, Yu, Y, Chen, Q, Yang, J. | 登録日 | 2015-06-30 | 公開日 | 2015-11-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.193 Å) | 主引用文献 | Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. Febs J., 283, 2016
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8S9B
| Cryo-EM structure of Nav1.7 with LCM | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2023-03-27 | 公開日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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8S9C
| Cryo-EM structure of Nav1.7 with CBZ | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2023-03-27 | 公開日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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3LD8
| Structure of JMJD6 and Fab Fragments | 分子名称: | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, FE (III) ION, GLYCEROL, ... | 著者 | Hong, X, Zang, J, White, J, Kappler, J.W, Wang, C, Zhang, G. | 登録日 | 2010-01-12 | 公開日 | 2010-08-04 | 最終更新日 | 2012-06-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Interaction of JMJD6 with single-stranded RNA. Proc.Natl.Acad.Sci.USA, 107, 2010
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