5GXO

Discovery of a compound that activates SIRT3 to deacetylate Manganese Superoxide Dismutase

Summary for 5GXO

• Entry DOI: 10.2210/pdb5gxo/pdb
• Descriptor: Superoxide dismutase [Mn], mitochondrial, MANGANESE (II) ION (3 entities in total)
• Functional Keywords: superoxide dismutase acetylation, oxidoreductase
• Biological source: Homo sapiens (Human)
• Cellular location: Mitochondrion matrix: P04179
• Total number of polymer chains: 2
• Total formula weight: 44658.16

Authors

Lu, J.,Li, J.,Wu, M.,Wang, J.,Xia, Q. (deposition date: 2016-09-19, release date: 2017-08-09, Last modification date: 2023-11-15)

• Primary citation: Lu, J.,Zhang, H.,Chen, X.,Zou, Y.,Li, J.,Wang, L.,Wu, M.,Zang, J.,Yu, Y.,Zhuang, W.,Xia, Q.,Wang, J.; A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase.; Free Radic. Biol. Med., 112:287-297, 2017; PubMed: 28711502; DOI: 10.1016/j.freeradbiomed.2017.07.012

Experimental method

X-RAY DIFFRACTION (2.3 Å)