5GXO
Discovery of a compound that activates SIRT3 to deacetylate Manganese Superoxide Dismutase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004784 | molecular_function | superoxide dismutase activity |
| A | 0006801 | biological_process | superoxide metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004784 | molecular_function | superoxide dismutase activity |
| B | 0006801 | biological_process | superoxide metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 301 |
| Chain | Residue |
| A | HIS50 |
| A | HIS98 |
| A | ASP183 |
| A | HIS187 |
| A | HOH424 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 301 |
| Chain | Residue |
| B | HOH428 |
| B | HIS50 |
| B | HIS98 |
| B | ASP183 |
| B | HIS187 |
Functional Information from PROSITE/UniProt
| site_id | PS00088 |
| Number of Residues | 8 |
| Details | SOD_MN Manganese and iron superoxide dismutases signature. DvWEHAYY |
| Chain | Residue | Details |
| A | ASP183-TYR190 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10852710, ECO:0000269|PubMed:11580280, ECO:0000269|PubMed:1394426, ECO:0000269|PubMed:19265433, ECO:0000269|PubMed:9537987, ECO:0000269|PubMed:9537988, ECO:0000312|PDB:1JA8, ECO:0007744|PDB:1AP5, ECO:0007744|PDB:1AP6, ECO:0007744|PDB:1EM1, ECO:0007744|PDB:1N0J, ECO:0007744|PDB:1QNM, ECO:0007744|PDB:1ZSP, ECO:0007744|PDB:1ZTE, ECO:0007744|PDB:1ZUQ, ECO:0007744|PDB:2P4K |
| Chain | Residue | Details |
| A | HIS50 | |
| A | HIS98 | |
| A | ASP183 | |
| A | HIS187 | |
| B | HIS50 | |
| B | HIS98 | |
| B | ASP183 | |
| B | HIS187 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000269|PubMed:10334867, ECO:0000269|PubMed:16399855 |
| Chain | Residue | Details |
| A | TYR58 | |
| B | TYR58 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P09671 |
| Chain | Residue | Details |
| A | ALY68 | |
| A | LYS75 | |
| A | LYS122 | |
| A | LYS130 | |
| B | ALY68 | |
| B | LYS75 | |
| B | LYS122 | |
| B | LYS130 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P09671 |
| Chain | Residue | Details |
| A | LYS114 | |
| A | LYS202 | |
| B | LYS114 | |
| B | LYS202 |
