4GOV

The crystal structure of human fascin 1 S39D mutant

Summary for 4GOV

Entry DOI	10.2210/pdb4gov/pdb
Related	4GOY 4GP0 4GP3
Descriptor	Fascin, BROMIDE ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	beta-trefoil, actin bundling protein, cancer, metastasis, cell migration, actin-binding, phosphoprotein, protein binding, actin
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton: Q16658
Total number of polymer chains	2
Total formula weight	111275.28
Authors	Yang, S.Y.,Huang, F.K.,Huang, J.,Chen, S.,Jakoncic, J.,Leo-Macias, A.,Diaz-Avalos, R.,Chen, L.,Zhang, J.J.,Huang, X.Y. (deposition date: 2012-08-20, release date: 2012-11-28, Last modification date: 2023-09-13)
Primary citation	Yang, S.,Huang, F.K.,Huang, J.,Chen, S.,Jakoncic, J.,Leo-Macias, A.,Diaz-Avalos, R.,Chen, L.,Zhang, J.J.,Huang, X.Y. Molecular mechanism of fascin function in filopodial formation. J.Biol.Chem., 288:274-284, 2013 Cited by PubMed: 23184945 DOI: 10.1074/jbc.M112.427971 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation