7TOB

Crystal structure of the SARS-CoV-2 Omicron main protease (Mpro) in complex with inhibitor GC376

Summary for 7TOB

• Entry DOI: 10.2210/pdb7tob/pdb
• Descriptor: 3C-like proteinase nsp5, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• Functional Keywords: omicron, main protease, 3cl, 3-chemotrypsin like protease, sars-cov-2, covid, gc376, inhibitor, covalent, antiviral, nsp5, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 1
• Total formula weight: 34564.37

Authors

Sacco, M.D.,Wang, J.,Chen, Y. (deposition date: 2022-01-24, release date: 2022-02-02, Last modification date: 2023-10-18)

• Primary citation: Sacco, M.D.,Hu, Y.,Gongora, M.V.,Meilleur, F.,Kemp, M.T.,Zhang, X.,Wang, J.,Chen, Y.; The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition.; Cell Res., 32:498-500, 2022; PubMed: 35292745; DOI: 10.1038/s41422-022-00640-y

Experimental method

X-RAY DIFFRACTION (2.05 Å)