6GK8
 
 | | Crystal structure of anti-tau antibody dmCBTAU-28.1, double mutant (S32R, E35K) of CBTAU-28.1, in complex with Tau peptide A7731 (residues 52-71) | | 分子名称: | CHLORIDE ION, HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-28.1(S32R;E35K), TAU PEPTIDE A7731 (RESIDUES 52-71) | | 著者 | Steinbacher, S, Mrosek, M, Juraszek, J. | | 登録日 | 2018-05-18 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
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6GK7
 | | Crystal structure of anti-tau antibody dmCBTAU-27.1, double mutant (S31Y, T100I) of CBTAU-27.1, in complex with Tau peptide A8119B (residues 299-318) | | 分子名称: | CHLORIDE ION, HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I), HUMAN TAU PEPTIDE A8119 RESIDUES 299-318 | | 著者 | Steinbacher, S, Mrosek, M, Juraszek, J. | | 登録日 | 2018-05-18 | | 公開日 | 2018-06-13 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
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5JRP
 | | crystal structure of monoclonal antibody MR78 Fab | | 分子名称: | SODIUM ION, marberg virus monoclonal antibody MR78 Fab heavy chain, marberg virus monoclonal antibody MR78 Fab light chain | | 著者 | Dong, J, Crowe, J. | | 登録日 | 2016-05-06 | | 公開日 | 2017-11-08 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
Structure, 25, 2017
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4ZV6
 | | Crystal structure of the artificial alpharep-7 octarellinV.1 complex | | 分子名称: | AlphaRep-7, Octarellin V.1 | | 著者 | Figueroa, M, Sleutel, M, Urvoas, A, Valerio-Lepiniec, M, Minard, P, Martial, J.A, van de Weerdt, C. | | 登録日 | 2015-05-18 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.
J.Struct.Biol., 195, 2016
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1BH1
 | | STRUCTURAL STUDIES OF D-PRO MELITTIN, NMR, 20 STRUCTURES | | 分子名称: | MELITTIN | | 著者 | Barnham, K.J, Hewish, D, Werkmeister, J, Curtain, C, Kirkpatrick, A, Bartone, N, Liu, S.T, Norton, R, Rivett, D. | | 登録日 | 1998-06-11 | | 公開日 | 1999-01-06 | | 最終更新日 | 2022-02-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and activity of D-Pro14 melittin.
J.Protein Chem., 21, 2002
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5BOP
 | | Crystal structure of the artificial nanobody octarellinV.1 complex | | 分子名称: | Nanobody, Octarellin V.1 | | 著者 | Figueroa, M, Sleutel, M, Pardon, E, Steyaert, J, Martial, J.A, van de Weerdt, C. | | 登録日 | 2015-05-27 | | 公開日 | 2016-05-25 | | 最終更新日 | 2016-06-08 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.
J.Struct.Biol., 195, 2016
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7U0C
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7U0B
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6P9J
 | | crystal structure of human anti staphylococcus aureus antibody STAU-229 Fab | | 分子名称: | TRIS(HYDROXYETHYL)AMINOMETHANE, human anti staphylococcus aureus antibody STAU-229 Fab heavy chain, human anti staphylococcus aureus antibody STAU-229 Fab light chain | | 著者 | Dong, J, Crowe, J.E. | | 登録日 | 2019-06-10 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Human V H 1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis.
Mbio, 10, 2019
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5ERB
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6P9I
 | | crystal structure of human anti staphylococcus aureus antibody STAU-399 Fab | | 分子名称: | human anti staphylococcus aureus antibody STAU-399 Fab heavy chain, human anti staphylococcus aureus antibody STAU-399 Fab light chain | | 著者 | Dong, J, Crowe, J.E. | | 登録日 | 2019-06-10 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Human V H 1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis.
Mbio, 10, 2019
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6P9H
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5WEQ
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5MG2
 | | Crystal structure of the second bromodomain of human TAF1 in complex with BAY-299 chemical probe | | 分子名称: | 1,2-ETHANEDIOL, 6-(3-oxidanylpropyl)-2-(1,3,6-trimethyl-2-oxidanylidene-benzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione, Transcription initiation factor TFIID subunit 1 | | 著者 | Tallant, C, Bouche, L, Holton, S.J, Fedorov, O, Siejka, P, Picaud, S, Krojer, T, Srikannathasan, V, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hartung, I.V, Haendler, B, Muller, S, Huber, K.V.M, Structural Genomics Consortium (SGC) | | 登録日 | 2016-11-20 | | 公開日 | 2017-05-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains.
J. Med. Chem., 60, 2017
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5UFU
 | | Structure of AMPK bound to activator | | 分子名称: | 1,4:3,6-dianhydro-2-O-(6-chloro-5-{4-[1-(hydroxymethyl)cyclopropyl]phenyl}-1H-benzimidazol-2-yl)-D-mannitol, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, ... | | 著者 | Calabrese, M.F, Kurumbail, R.G. | | 登録日 | 2017-01-05 | | 公開日 | 2017-05-17 | | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | | 主引用文献 | Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
Cell Metab., 25, 2017
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6H06
 | | FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 | | 分子名称: | GLYCEROL, HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-22.1, HUMAN FAB ANTIBODY FRAGMENT OF HCBTAU-22.1, ... | | 著者 | Juraszek, J, Steinbacher, S. | | 登録日 | 2018-07-06 | | 公開日 | 2018-07-25 | | 最終更新日 | 2020-03-11 | | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | | 主引用文献 | Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422containing epitope on pathological tau.
Acta Neuropathol Commun, 6, 2018
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7LQK
 | | Crystal structure of the R375A mutant of LeuT | | 分子名称: | ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | | 著者 | Font, J, Aguilar, J, Galli, A, Ryan, R. | | 登録日 | 2021-02-13 | | 公開日 | 2021-05-19 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
Elife, 10, 2021
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7LQJ
 | | Crystal structure of LeuT bound to L-Alanine | | 分子名称: | ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | | 著者 | Font, J, Aguilar, J, Galli, A, Ryan, R. | | 登録日 | 2021-02-13 | | 公開日 | 2021-05-19 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.144 Å) | | 主引用文献 | Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
Elife, 10, 2021
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7LQL
 | | Crystal structure of the R375D mutant of LeuT | | 分子名称: | ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | | 著者 | Font, J, Aguilar, J, Galli, A, Ryan, R. | | 登録日 | 2021-02-13 | | 公開日 | 2021-05-19 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
Elife, 10, 2021
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6H0E
 | | FAB dmCBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-23 | | 分子名称: | GLYCEROL, HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1, Microtubule-associated protein tau | | 著者 | Juraszek, J, Steinbacher, S. | | 登録日 | 2018-07-09 | | 公開日 | 2018-07-25 | | 最終更新日 | 2020-03-11 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422containing epitope on pathological tau.
Acta Neuropathol Commun, 6, 2018
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7QOX
 | | Factor XI and Plasma Kallikrein apple domain structures reveals different kininogen bound complexes | | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... | | 著者 | Li, C, Awital, B, Wong, S, Dreveny, I, Meijers, J, Emsley, J. | | 登録日 | 2021-12-29 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.
J Thromb Haemost, 17, 2019
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7QOT
 | | Factor XI and Plasma Kallikrein apple domain structures reveals different kininogen bound complexes | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XIa heavy chain, Kininogen-1 light chain, ... | | 著者 | Li, C, Awital, B, Wong, S, Dreveny, I, Meijers, J, Emsley, J. | | 登録日 | 2021-12-28 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | | 主引用文献 | Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.
J Thromb Haemost, 17, 2019
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5V7R
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5V7U
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3B9S
 | | Macrophage Migration Inhibitory Factor (MIF) complexed with Inhibitor, 4-IPP. | | 分子名称: | 4-phenylpyrimidine, GLYCEROL, Macrophage Migration Inhibitory Factor, ... | | 著者 | Zierow, S, Crichlow, G, Lolis, E. | | 登録日 | 2007-11-06 | | 公開日 | 2008-09-23 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells.
Cancer Res., 68, 2008
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