6H06

FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5

Summary for 6H06

Entry DOI	10.2210/pdb6h06/pdb
Descriptor	HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-22.1, HUMAN FAB ANTIBODY FRAGMENT OF HCBTAU-22.1, Microtubule-associated protein tau, ... (5 entities in total)
Functional Keywords	fab, tau peptide, complex, immune system
Biological source	Homo sapiens More
Total number of polymer chains	12
Total formula weight	203703.04
Authors	Juraszek, J.,Steinbacher, S. (deposition date: 2018-07-06, release date: 2018-07-25, Last modification date: 2020-03-11)
Primary citation	van Ameijde, J.,Crespo, R.,Janson, R.,Juraszek, J.,Siregar, B.,Verveen, H.,Sprengers, I.,Nahar, T.,Hoozemans, J.J.,Steinbacher, S.,Willems, R.,Delbroek, L.,Borgers, M.,Dockx, K.,Van Kolen, K.,Mercken, M.,Pascual, G.,Koudstaal, W.,Apetri, A. Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422containing epitope on pathological tau. Acta Neuropathol Commun, 6:59-59, 2018 Cited by PubMed: 30001207 DOI: 10.1186/s40478-018-0562-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.63 Å)

Structure validation